Mixed spindle and epithelioid cell type gastrointestinal stromal tumor of the esophagus: a case report

被引：1

作者：

Korehisa, Shotaro ^{[1
]}

Saeki, Hiroshi ^{[1
]}

Nakashima, Yuichiro ^{[1
]}

Nakaji, Yu ^{[1
,2
]}

Tsutsumi, Satoshi ^{[1
]}

Yukaya, Takafumi ^{[1
]}

Tajiri, Hirotada ^{[1
]}

Kasagi, Yuta ^{[1
]}

Sonoda, Hideto ^{[1
]}

Sugiyama, Masahiko ^{[1
]}

Ohgaki, Kippei ^{[1
]}

Oki, Eiji ^{[1
]}

Hirahashi, Minako ^{[2
]}

Yamamoto, Hidetaka ^{[2
]}

Maehara, Yoshihiko ^{[1
]}

机构：

[1] Kyushu Univ, Grad Sch Med Sci, Dept Surg & Sci, Higashi Ku, 3-1-1 Maidashi, Fukuoka 8128582, Japan

[2] Kyushu Univ, Grad Sch Med Sci, Dept Anat Pathol, Pathol Sci, Fukuoka, Japan

来源：

ESOPHAGUS | 2016年 / 13卷 / 03期

关键词：

Gastrointestinal stromal tumor; Spindle cell type; Epithelioid cell type; KIT;

D O I：

10.1007/s10388-016-0525-9

中图分类号：

R57 [消化系及腹部疾病];

学科分类号：

摘要：

Fewer than 1 % of gastrointestinal stromal tumors (GISTs) are of the esophagus. This report describes a 63-year-old female diagnosed with mixed spindle/epithelioid cell GIST of the esophagus. She was admitted to our hospital with symptoms of nausea and hematemesis. Preoperative imaging showed a huge submucosal tumor in the lower thoracic and abdominal esophagus. Pathologic examination of an endoscopic biopsy sample suggested squamous cell carcinoma. She underwent subtotal esophagectomy and reconstruction with a gastric tube. Postoperative pathological diagnosis revealed a mixed spindle/epithelioid cell type GIST. The tumor measured 8 x 6 cm, with 30-50 mitotic counts per high power field, immunohistochemical positivity for C-kit (CD117) and CD34 and high risk by modified Fletcher classification. Adjuvant chemotherapy with imatinib mesylate was started 3 months after surgery. Preoperative pathological examination, including staining for CD117 and CD34, of biopsy samples of apparently stromal tumors may be required to rule out rare subtypes of GIST.

引用

页码：301 / 305

页数：5

共 11 条

[1]

Attili Suresh V, 2011, Gastrointest Cancer Res, V4, P173

[2]

Cichoz-Lach Halina, 2008, Pol Arch Med Wewn, V118, P216

[3] Gastrointestinal stromal tumors: The histology report [J].