An improved formal total synthesis of (-)-anisomycin

被引：18

作者：

Huang, PQ ^{[1
]}

Zheng, X ^{[1
]}

机构：

[1] Xiamen Univ, Dept Chem, Xiamen 361005, Fujian, Peoples R China

来源：

ARKIVOC | 2003年

关键词：

anisomycin; malic acid; reductive alkylation; asymmetric synthesis; malimide;

D O I：

10.3998/ark.5550190.0004.202

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

(R)-1-Benzyloxycarbonyl-2-(4-methoxyphenyl) methyl-3-pyrroline 14 was synthesized from (S)-N, O-dibenzyl malimide 5 via a highly regio and trans stereoselective reductive alkylation of 5. This constitutes an improved formal asymmetric synthesis of natural (-)- anisomycin.

引用

页码：7 / 14

页数：8

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