Biocompatible and biodegradable MOPEO-b-PCL diblock copolymer micelles as nanocontainers for drugs

被引：0

作者：

Partsevskaya, S. V. ^{[1
]}

Zheltonozhskaya, T. B. ^{[1
]}

Permyakova, N. M. ^{[1
]}

Kolendo, A. Y. ^{[1
]}

机构：

[1] Kiev Natl Taras Shevchenko Univ, Fac Chem, Dept Macromol Chem, UA-01033 Kiev, Ukraine

来源：

MATERIALWISSENSCHAFT UND WERKSTOFFTECHNIK | 2011年 / 42卷 / 02期

关键词：

diblock copolymer; micellization; hydrogen bonding; drug delivery; DELIVERY VEHICLE; BLOCK-COPOLYMERS; RELEASE; AGENTS;

D O I：

10.1002/mawe.201100743

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Amphiphilic MOPEO-b-PCL diblock copolymers with biocompatible and biodegradable blocks of methoxypoly(ethylene oxide) (M(v) = 2 . 10(3)) and poly(epsilon-caprolactone) of a variable chain length were synthesized. Their structure, the micellization in dioxane/aqueous solutions and also the interaction of micelles with the model drug prednisolon (PS) were studied by (1)H NMR, DSC, UV/visible spectroscopy, static light scattering and FTIR. A binding of PS by micellar nanocontainers by means of hydrogen bonds and hydrophobic interactions, that enhances essentially the stability of micellar structures in a solution, was established.

引用

页码：123 / 130

页数：8

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