Determination of benzimidazole residues in bovine milk by ultra-high performance liquid chromatography-tandem mass spectrometry

被引：35

作者：

Xia, Xi ^{[1
]}

Dong, Yichun ^{[2
]}

Luo, Pengjie ^{[1
]}

Wang, Xia ^{[2
]}

Li, Xiaowei ^{[1
]}

Ding, Shuangyang ^{[1
]}

Shen, Jianzhong ^{[1
]}

机构：

[1] China Agr Univ, Dept Pharmacol & Toxicol, Coll Vet Med, Beijing 100193, Peoples R China

[2] China Inst Vet Drug Control, Beijing 100081, Peoples R China

来源：

JOURNAL OF CHROMATOGRAPHY B-ANALYTICAL TECHNOLOGIES IN THE BIOMEDICAL AND LIFE SCIENCES | 2010年 / 878卷 / 30期

关键词：

Benzimidazole; Ultra-high performance liquid chromatography; Tandem mass spectrometry; Milk; BIOLOGICAL MATRICES; LIVER; ANTHELMINTICS; METABOLITES; MEBENDAZOLE; FLUBENDAZOLE; VALIDATION; MUSCLE; DRUG;

D O I：

10.1016/j.jchromb.2010.09.026

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

A method based on ultra-high performance liquid chromatography coupled with electrospray ionization tandem mass spectrometry (UHPLC-MS/MS) for the simultaneous determination of benzimidazole residues in bovine milk has been optimized and validated. Rapid chromatographic separation of 13 analytes in 8 min was obtained by means of UHPLC. The samples were subject to Oasis MCX solid-phase extraction cartridges for extraction and clean-up. Matrix-matched calibration curves were performed to compensate for the matrix effect and loss in sample preparation. Mean recoveries ranged from 80% to 101% and inter-day precision was lower than 14%. Limit of detection and limit of quantification of the method ranged from 0.01 to 0.5 mu g L-1 and from 0.1 to 10 mu g L-1, respectively. (C) 2010 Elsevier B.V. All rights reserved.

引用

页码：3174 / 3180

页数：7

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