Emerging of two new subgenotypes of porcine reproductive and respiratory syndrome viruses in Southeast China

被引：15

作者：

Zhang, Qiaoya ^{[1
]}

Xu, Xiaojie ^{[1
]}

You, Shumei ^{[1
]}

Li, Yufeng ^{[1
]}

Wang, Haiyan ^{[1
]}

Bai, Juan ^{[1
]}

Jiang, Ping ^{[1
,2
]}

机构：

[1] Nanjing Agr Univ, Coll Vet Med, Minist Agr, Key Lab Anim Dis Diagnost & Immunol, Nanjing 210095, Jiangsu, Peoples R China

[2] Jiangsu Coinnovat Ctr Prevent & Control Important, Yangzhou, Jiangsu, Peoples R China

来源：

MICROBIAL PATHOGENESIS | 2016年 / 97卷

关键词：

Porcine reproductive and respiratory syndrome virus (PRRSV); GP5; Nsp2; Subgenotypes; Southeast China; GENETIC DIVERSITY; SWINE INFERTILITY; PRRSV; EVOLUTIONARY; EMERGENCE; GP5; IDENTIFICATION; DISSECTION; DISEASE; NSP2;

D O I：

10.1016/j.micpath.2016.05.011

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Porcine reproductive and respiratory syndrome virus (PRRSV) is one of the leading swine pathogens and causes major economic loss to the global swine industry. In this study, a total of 49 PRRSV isolates were collected from different swine herds in seven provinces in Southeast China from 2014 to 2015. All the ORF5 genes and some Nsp2 genes were sequenced. Phylogenetic analysis showed that all the isolates belonged to the North America genotype. Among them, five isolates formed a new subgenotype IV derived from highly pathogenic PRRSV (HP-PRRSV). Six isolates formed subgenotype III, which were closely related to the NADC30 strain in the US. These isolates formed 13 putative N-linked glycosylation site (NGS) patterns based on N30, 33, 34, 35, 44 and 51. There were fewer NGS5 of isolates in subgenotype IV than in subgenotype III. This indicates that the two new subgenotypes of PRRSV strains with different NGS patterns were spreading in those regions of China. The genetic diversity should be considered for the control and prevention of this disease. (C) 2016 Elsevier Ltd. All rights reserved.

引用

页码：27 / 33

页数：7

共 38 条

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