[Rh(CO)2Cl]2-catalyzed domino reactions involving allylic substitution and subsequent carbocyclization reactions

被引：35

作者：

Ashfeld, BL ^{[1
]}

Miller, KA ^{[1
]}

Smith, AJ ^{[1
]}

Tran, K ^{[1
]}

Martin, SF ^{[1
]}

机构：

[1] Univ Texas, Dept Chem & Biochem, Austin, TX 78712 USA

来源：

ORGANIC LETTERS | 2005年 / 7卷 / 08期

关键词：

D O I：

10.1021/ol0504300

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Three novel domino reaction processes have been discovered and developed that employ the regioselective and stereoselective [Rh(CO)(2)Cl](2)-catalyzed alkylations of allylic trifluoroacetates with alpha-substituted sodiomalonates followed by an intramolecular Pauson-Khand annulation, a [5 + 2] cycloaddition, or a cycloisomerization. A unique aspect of the methodology is that a single catalyst is used to effect sequential transformations simply by increasing the temperature for the second reaction.

引用

页码：1661 / 1663

页数：3

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