Melongenaterpenes A-L, Vetispirane-Type Sesquiterpenoids from the Roots of Solanum melongena

被引：20

作者：

Yin, Xin ^{[1
,2
]}

Liu, Yan ^{[1
]}

Pan, Juan ^{[1
]}

Ye, Hong-Liang ^{[1
]}

Sun, Yan ^{[1
]}

Zhao, Dong-Ying ^{[1
]}

Kuang, Hai-Xue ^{[1
]}

Yang, Bing-You ^{[1
]}

机构：

[1] Heilongjiang Univ Chinese Med, Minist Educ, Key Lab Chinese Mat Med, Harbin 150040, Peoples R China

[2] Guizhou Univ Tradit Chinese Med, Guiyang 550000, Peoples R China

来源：

JOURNAL OF NATURAL PRODUCTS | 2019年 / 82卷 / 12期

基金：

中国博士后科学基金;

关键词：

GLYCOSIDES; STEREOCHEMISTRY; METABOLITES; DERIVATIVES; LUBIMIN;

D O I：

10.1021/acs.jnatprod.9b00206

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

Melongenaterpenes A-L (1-12), 12 new sesquiterpenoids with rare spiro[4.5]decane skeletons, were isolated from the roots of Solanum melongena. Their 2D structures and relative configurations were determined based on NMR and HRESIMS data. The absolute configuration of melongenaterpene A (1) was defined by X-ray crystallographic analysis. The absolute configurations of the remaining compounds were determined by comparison of their NMR data with 1 and consideration of the biosynthetic pathway. This is the first report of the crystal structure of a vetispirane-type sesquiterpenoid. None of the compounds exhibited cytotoxic activity against the three human cancer cell lines HepG2, HeLa, and MCF-7.

引用

页码：3242 / 3248

页数：7

共 20 条

[1] VETISPIRANE SESQUITERPENE GLUCOSIDES FROM FLUE-CURED VIRGINIA TOBACCO - STRUCTURE, ABSOLUTE STEREOCHEMISTRY, AND SYNTHESIS - X-RAY STRUCTURE OF PARA-BROMOBENZENESULFONATE OF ONE OF DERIVED AGLYCONES [J].