Lack of bidirectional association between age-related macular degeneration and Alzheimer's disease: A Mendelian randomization study

被引：11

作者：

Jiang, Li ^{[1
]}

Li, Jin-Chen ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Tang, Bei-Sha ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Guo, Ji-Feng ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

Shen, Lu ^{[1
,2
,3
,4
,5
,6
,7
,8
]}

机构：

[1] Cent South Univ, Dept Neurol, Xiangya Hosp, 87 Xiangya Rd, Changsha 410008, Hunan, Peoples R China

[2] Cent South Univ, Key Lab Hunan Prov Neurodegenerat Disorders, Changsha, Hunan, Peoples R China

[3] Hunan Int Sci & Technol Cooperat Base Neurodegene, Changsha, Peoples R China

[4] Cent South Univ, Ctr Med Genet, Sch Life Sci, Changsha, Hunan, Peoples R China

[5] Cent South Univ, Hunan Key Lab Med Genet, Sch Life Sci, Changsha, Hunan, Peoples R China

[6] Cent South Univ, Engn Res Ctr Hunan Prov Cognit Impairment Disorde, Changsha, Peoples R China

[7] Cent South Univ, Bioinformat Ctr, Xiangya Hosp, Changsha, Peoples R China

[8] Cent South Univ, Natl Clin Res Ctr Geriatr Disorders, Xiangya Hosp, Changsha, Peoples R China

来源：

ALZHEIMERS & DEMENTIA | 2022年 / 18卷 / 12期

基金：

中国国家自然科学基金;

关键词：

age-related macular degeneration; Alzheimer's disease; Mendelian randomization; DEMENTIA;

D O I：

10.1002/alz.12775

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Introduction Observational studies have reported inconsistent results on the relationship between age-related macular degeneration (AMD) and Alzheimer's disease (AD). Therefore, we aimed to determine whether there is a causal association between AMD and AD. Methods This two-sample bidirectional Mendelian randomization (MR) study evaluated causal associations between advanced AMD and AD using summary data from large genome-wide association studies. Results Genetic liability for advanced AMD showed no statistical causal association with AD risk (odds ratio [OR] = 0.999, 95% confidence interval [CI]: 0.955-1.044, P = .948). Reverse MR analysis provided little support for a causal effect of AD on advanced AMD (OR = 0.973, 95%CI: 0.938-1.008, P = .133). Discussion This MR study found no evidence to support a bidirectional causality between advanced AMD and AD. Highlights We evaluated the bidirectional causal relationship between advanced AMD and AD. Advanced AMD showed no statistical causal association with risk of AD. We found no evidence to support a causal effect of AD on advanced AMD risk. The associations observed in epidemiological studies should not be considered causal.

引用

页码：2725 / 2729

页数：5

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