Copper-Catalyzed N-Formylation of Amines through Tandem Amination/Hydrolysis/Decarboxylation Reaction of Ethyl Bromodifluoroacetate

被引：27

作者：

Li, Xiao-Fang ^{[1
]}

Zhang, Xing-Guo ^{[1
]}

Chen, Fan ^{[1
]}

Zhang, Xiao-Hong ^{[1
]}

机构：

[1] Wenzhou Univ, Coll Chem & Mat Engn, Wenzhou 325035, Peoples R China

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 20期

基金：

中国国家自然科学基金;

关键词：

SOLVENT-FREE CONDITIONS; CARBON-DIOXIDE; ROOM-TEMPERATURE; SODIUM BROMODIFLUOROACETATE; OXIDATIVE FORMYLATION; REFORMATSKY REACTION; MOLECULAR-OXYGEN; SECONDARY-AMINES; MILD CONDITIONS; ARYL BROMIDES;

D O I：

10.1021/acs.joc.8b01555

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Ethyl bromodifluoroacetate (BrCF2COOEt) was first used as the N-formylating reagent in the copper-catalyzed N-formylation of amines. A range of primary, secondary, cyclic arylamines, and aliphatic amines underwent the N-formylation smoothly to furnish the N-formamides in moderate-to-excellent yields.

引用

页码：12815 / 12821

页数：7

共 36 条

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