Suppression by calmodulin of glutamate-induced potassium current in identified snail neurons

被引：4

作者：

Onozuka, M ^{[1
]}

Watanabe, K ^{[1
]}

机构：

[1] GIFU UNIV,SCH MED,DEPT PHYSIOL,GIFU 500,JAPAN

来源：

NEUROSCIENCE LETTERS | 1996年 / 204卷 / 1-2期

关键词：

glutamate; glutamate receptors; calmodulin; outward potassium current; N-(6-aminohexyl)-5-chloro-1-naphthalene-sulfonamide (W-7); snail neurons;

D O I：

10.1016/0304-3940(96)12327-2

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Using the voltage-clamp technique combined with pressure injection, we examined the inhibitory action of glutamate (Glu) in identified snail neurons. Calimidazolium and N-(6-aminohexyl)-5-chloro-1-naphthalenesulfonamide (W-7), calmodulin inhibitors, enhanced a slow outward current (Glu current) induced by Glu in a dose-dependent manner. This Glu current was suppressed by intracellular injection of calmodulin. However, no significant change in the Glu current was observed when either CaCl2 or EGTA was intracellularly applied. These results suggest a novel calmodulin-mediated process, through which Glu induces an outward current.

引用

页码：105 / 108

页数：4

共 20 条

[1] DIFFERENT TYPES OF GLUTAMATE RECEPTORS IN ISOLATED AND IDENTIFIED NEURONS OF THE MOLLUSK PLANORBARIUS-CORNEUS [J].