Synthesis of 5-Aryl-3(2H)-furanones Using Intramolecular Cyclization of Sulfonium Salts

被引：16

作者：

Inagaki, Sho ^{[1
]}

Saito, Kai ^{[1
]}

Suto, Soichiro ^{[1
]}

Aihara, Hiromi ^{[1
]}

Sugawara, Aoi ^{[1
]}

Tamura, Satoru ^{[1
]}

Kawano, Tomikazu ^{[1
]}

机构：

[1] Iwate Med Univ, Sch Pharm, Dept Med & Organ Chem, Yahaba, Iwate 0283694, Japan

来源：

JOURNAL OF ORGANIC CHEMISTRY | 2018年 / 83卷 / 22期

关键词：

BETA-DIKETONES; FACILE SYNTHESIS; 3(2H)-FURANONES; CONSTRUCTION; INHIBITORS; ARYLATION; KETONES; ESTERS; ROUTE;

D O I：

10.1021/acs.joc.8b02153

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Base-induced intramolecular cyclization of novel (4-aryl-2,4-dioxobutyl)methylphenylsulfonium salts prepared from the commercially available 1-arylethanone by a cost-effective process is described in this paper. The reaction was completed within 10 min to produce a family of 2-unsubstituted S-aryl-3(2H)-furanones in excellent yield. This procedure is simple, and can be carried out under mild conditions and an ambient atmosphere.

引用

页码：13834 / 13846

页数：13

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