Reduced cerebrospinal fluid ethanolamine concentration in major depressive disorder

被引：38

作者：

Ogawa, Shintaro ^{[1
,7
]}

Hattori, Kotaro ^{[1
,2
]}

Sasayama, Daimei ^{[1
,3
]}

Yokota, Yuki ^{[1
,2
]}

Matsumura, Ryo ^{[1
,2
]}

Matsuo, Junko ^{[1
,7
]}

Ota, Miho ^{[1
]}

Hori, Hiroaki ^{[1
]}

Teraishi, Toshiya ^{[1
]}

Yoshida, Sumiko ^{[4
]}

Noda, Takamasa ^{[4
]}

Ohashi, Yoshiaki ^{[5
]}

Sato, Hajime ^{[5
]}

Higuchi, Teruhiko ^{[6
]}

Motohashi, Nobutaka ^{[7
]}

Kunugi, Hiroshi ^{[1
]}

机构：

[1] Natl Ctr Neurol & Psychiat, Natl Inst Neurosci, Dept Mental Disorder Res, Kodaira, Tokyo 1878502, Japan

[2] Natl Ctr Neurol & Psychiat, Translat Med Ctr, Kodaira, Tokyo 1878551, Japan

[3] Shinshu Univ, Sch Med, Dept Psychiat, Matsumoto, Nagano 3908621, Japan

[4] Natl Ctr Neurol & Psychiat, Natl Ctr Hosp, Dept Psychiat, Kodaira, Tokyo 1878551, Japan

[5] Human Metabolome Technol Inc, Tsuruoka, Yamagata 9970052, Japan

[6] Natl Ctr Neurol & Psychiat, Kodaira, Tokyo 1878551, Japan

[7] Univ Yamanashi, Interdisciplinary Grad Sch Med & Engn, Dept Neuropsychiat, Chuo Ku, Yamanashi 4093898, Japan

来源：

SCIENTIFIC REPORTS | 2015年 / 5卷

关键词：

GAMMA-AMINOBUTYRIC-ACID; VAGUS NERVE-STIMULATION; EXCITATORY AMINO-ACIDS; ENDOCANNABINOID SYSTEM; CSF-GABA; PLASMA; SCHIZOPHRENIA; METABOLITES; BIOMARKERS; BLOOD;

D O I：

10.1038/srep07796

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Amino acids play key roles in the function of the central nervous system, and their alterations are implicated in psychiatric disorders. In the search for a biomarker for major depressive disorder (MDD), we used high-performance liquid chromatography to measure amino acids and related molecules in the cerebrospinal fluid (CSF) of 52 patients withMDD(42 depressed and 10 remitted; DSM-IV) and 54 matched controls. Significant differences were found in four amino acid concentrations between the depressed patients and controls. After Bonferroni correction, only ethanolamine (EA) levels remained significantly reduced in depressed patients (nominal P = 0.0000011). A substantial proportion of the depressed patients (40.5%) showed abnormally low CSF EA levels (<12.1 mu M) (P = 0.000033; OR = 11.6, 95% CI: 3.1-43.2). When patients with low EA and those with high EA levels were compared, the former had higher scores for overall depression severity (P = 0.0033) and 'Somatic Anxiety' symptoms (P = 0.00026). In unmedicated subjects, CSF EA levels showed a significant positive correlation with levels of homovanillic acid (P = 0.0030) and 5-hydroxyindoleacetic acid (P = 0.019). To our knowledge, this is the first study showing that patients with MDD have significantly lower CSF EA concentrations compared with control subjects. CSF EA could be a state-dependent biomarker for a subtype of MDD.

引用

页数：8

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