Anti-Tumour Effect Of A Chitosan Delivery System For Doxorubicin

被引：1

作者：

Tan, Mei Lin ^{[1
]}

Choong, Peter F. M. ^{[1
]}

Dass, Crispin R. ^{[1
]}

机构：

[1] St Vincents Hosp Melbourne, Dept Orthopaed, Melbourne, Vic, Australia

来源：

FUNCTIONALIZED AND SENSING MATERIALS | 2010年 / 93-94卷

关键词：

chitosan; delivery; complex; doxorubicin; cancer; HUMAN OSTEOSARCOMA; NANOPARTICLES; CANCER; MODEL; BONE;

D O I：

10.4028/www.scientific.net/AMR.93-94.703

中图分类号：

T [工业技术];

学科分类号：

08 ;

摘要：

Used against a variety of tumours, doxorubicin (DOX), causes multiple side-effects in patients, especially in high doses required to control tumour growth. A drug delivery system (DDS) was developed to deliver DOX. Through DOX encapsulation into chitosan DDS, novel DOX microparticles (DMPs) were formed. Multiple optimisation steps produced DMPs which caused tumour cell death. Treatment of mice bearing tumours with DMP decreased tumour growth and spread, with no visible side-effects. There are plans to evaluate this delivery vehicle more closely towards clinical development and testing.

引用

页码：703 / 706

页数：4

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