Decelerated genome evolution in modern vertebrates revealed by analysis of multiple lancelet genomes

被引：110

作者：

Huang, Shengfeng ^{[1
]}

Chen, Zelin ^{[1
]}

Yan, Xinyu ^{[1
]}

Yu, Ting ^{[1
]}

Huang, Guangrui ^{[1
]}

Yan, Qingyu ^{[1
]}

Pontarotti, Pierre Antoine ^{[2
]}

Zhao, Hongchen ^{[1
]}

Li, Jie ^{[1
]}

Yang, Ping ^{[1
]}

Wang, Ruihua ^{[1
]}

Li, Rui ^{[1
]}

Tao, Xin ^{[1
]}

Deng, Ting ^{[1
]}

Wang, Yiquan ^{[3
,4
]}

Li, Guang ^{[3
,4
]}

Zhang, Qiujin ^{[5
]}

Zhou, Sisi ^{[1
]}

You, Leiming ^{[1
]}

Yuan, Shaochun ^{[1
]}

Fu, Yonggui ^{[1
]}

Wu, Fenfang ^{[1
]}

Dong, Meiling ^{[1
]}

Chen, Shangwu ^{[1
]}

Xu, Anlong ^{[1
,6
]}

机构：

[1] Sun Yat Sen Univ, Sch Life Sci, Guangdong Key Lab Pharmaceut Funct Genes, State Key Lab Biocontrol, Guangzhou 510275, Guangdong, Peoples R China

[2] Aix Marseille Univ, CNRS, Evolut Biol & Modelisat UMR 7353, F-13331 Marseille, France

[3] Xiamen Univ, Sch Life Sci, Xiamen 361005, Peoples R China

[4] Xiamen Univ, Shenzhen Res Inst, Shenzhen 518058, Peoples R China

[5] Fujian Normal Univ, Coll Life Sci, Fujian Key Lab Dev & Neuron Biol, Fuzhou 350108, Peoples R China

[6] Beijing Univ Chinese Med, Beijing 100029, Peoples R China

来源：

NATURE COMMUNICATIONS | 2014年 / 5卷

关键词：

AMPHIOXUS GENOME; ALIGNMENT; GENES; RNA; QUANTIFICATION; DUPLICATION; COMPLEXITY; TUNICATES; SEQUENCES; PROGRAM;

D O I：

10.1038/ncomms6896

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Vertebrates diverged from other chordates similar to 500 Myr ago and experienced successful innovations and adaptations, but the genomic basis underlying vertebrate origins are not fully understood. Here we suggest, through comparison with multiple lancelet (amphioxus) genomes, that ancient vertebrates experienced high rates of protein evolution, genome rearrangement and domain shuffling and that these rates greatly slowed down after the divergence of jawed and jawless vertebrates. Compared with lancelets, modern vertebrates retain, at least relatively, less protein diversity, fewer nucleotide polymorphisms, domain combinations and conserved non-coding elements (CNE). Modern vertebrates also lost substantial transposable element (TE) diversity, whereas lancelets preserve high TE diversity that includes even the long-sought RAG transposon. Lancelets also exhibit rapid gene turnover, pervasive transcription, fastest exon shuffling in metazoans and substantial TE methylation not observed in other invertebrates. These new lancelet genome sequences provide new insights into the chordate ancestral state and the vertebrate evolution.

引用

页数：12

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