Meat Consumption, Nonsteroidal Anti-Inflammatory Drug Use, and Mortality among Colorectal Cancer Patients in the California Teachers Study

被引:22
作者
Zell, Jason A. [1 ,2 ,3 ,4 ]
Ziogas, Argyrios [1 ,2 ]
Bernstein, Leslie [5 ,6 ]
Clarke, Christina A. [7 ]
Deapen, Dennis [8 ,9 ]
Largent, Joan A. [1 ,2 ]
Neuhausen, Susan L. [6 ]
Stram, Daniel O. [8 ,9 ]
Ursin, Giske [8 ,9 ]
Anton-Culver, Hoda [1 ,2 ]
机构
[1] Univ Calif Irvine, Genet Epidemiol Res Inst, Irvine, CA 92697 USA
[2] Univ Calif Irvine, Dept Epidemiol, Irvine, CA 92697 USA
[3] Univ Calif Irvine, Div Hematol Oncol, Irvine, CA 92697 USA
[4] Univ Calif Irvine, Chao Family Comprehens Canc Ctr, Irvine, CA 92697 USA
[5] City Hope Natl Med Ctr, Div Canc Etiol, Duarte, CA 91010 USA
[6] City Hope Natl Med Ctr, Dept Populat Sci, Duarte, CA 91010 USA
[7] Canc Prevent Inst Calif, Fremont, CA USA
[8] Univ So Calif, Keck Sch Med, Dept Prevent Med, Los Angeles, CA 90033 USA
[9] Univ So Calif, Norris Comprehens Canc Ctr, Los Angeles, CA 90033 USA
关键词
DIFLUOROMETHYLORNITHINE PLUS SULINDAC; ASPIRIN USE; ADENOMA RECURRENCE; RANDOMIZED-TRIAL; ARGININE INTAKE; RISK; COLON; PREVENTION; SURVIVAL; POLYMORPHISM;
D O I
10.1158/1940-6207.CAPR-09-0262
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
A low-meat diet and regular use of nonsteroidal anti-inflammatory drugs (NSAID) have been associated with decreased mortality among colorectal cancer (CRC) patients. Here, we investigated the association between prediagnosis usual meat consumption and CRC-specific mortality, and whether meat consumption modifies the previously noted association between NSAID use and CRC-specific mortality among women in the California Teachers Study cohort. Women joining the California Teachers Study in 1995-1996 without prior CRC diagnosis, diagnosed with incident CRC during follow-up through December 2007, were eligible for inclusion. Meat intake (frequency and serving size) and NSAID use (aspirin or ibuprofen use) were ascertained via self-administered questionnaires before diagnosis. Vital status and cause of death were determined by linkage with mortality files. Multivariable Cox proportional hazards regression models were used to estimate hazard ratios for death and 95% confidence intervals. Prediagnosis meat consumption was not associated with CRC-specific mortality among 704 CRC patients (and 201 CRC-specific deaths), comparing patients in the lowest consumption tertile (0-5.4 medium-sized servings/wk) to those in the higher consumption tertiles. Regular NSAID use (1-3 times/wk, 4-6 times/wk, daily) versus none was associated with decreased CRC-specific mortality among patients in the lowest meat consumption tertile (hazard ratio, 0.22; 95% CI, 0.06-0.82), but not among patients in the higher meat intake tertiles. The previously observed mortality risk reduction among female CRC patients associated with regular NSAID use was restricted to patients who reported low meat intake before diagnosis. These findings have implications for CRC survivorship and tertiary CRC prevention. Cancer Prev Res; 3(7); 865-75. (C) 2010 AACR.
引用
收藏
页码:865 / 875
页数:11
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