Nanoplasmonic biosensor: Coupling electrochemistry to localized surface plasmon resonance spectroscopy on nanocup arrays

被引：41

作者：

Zhang, Diming ^{[1
]}

Lu, Yanli ^{[1
]}

Jiang, Jing ^{[2
]}

Zhang, Qian ^{[1
]}

Yao, Yao ^{[1
]}

Wang, Ping ^{[1
]}

Chen, Bilian ^{[3
]}

Cheng, Qiaoyuan ^{[3
]}

Liu, Gang Logan ^{[2
]}

Liu, Qingjun ^{[1
,4
]}

机构：

[1] Zhejiang Univ, Dept Biomed Engn, Key Lab Biomed Engn, Biosensor Natl Special Lab,Educ Minist, Hangzhou 310027, Zhejiang, Peoples R China

[2] Univ Illinois, Micro & Nanotechnol Lab, Urbana, IL 61801 USA

[3] Zhejiang Inst Food & Drug Control, Hangzhou 310014, Zhejiang, Peoples R China

[4] Zhejiang Univ, Cyber Innovat Joint Res Ctr, Hangzhou 310027, Zhejiang, Peoples R China

来源：

BIOSENSORS & BIOELECTRONICS | 2015年 / 67卷

基金：

中国国家自然科学基金;

关键词：

Localized surface plasmon resonance (LSPR); Nanoscale cup arrays (nanoCA); Electrochemistry; Cyclic voltammetry (CV); Biosensor; ELECTROCATALYTIC ACTIVITY; GOLD NANOPARTICLES; PROTEIN ADSORPTION; SENSORS; DNA; OXIDASE;

D O I：

10.1016/j.bios.2014.08.022

中图分类号：

Q6 [生物物理学];

学科分类号：

071011 ;

摘要：

The nanoscale Lycurgus cup arrays were hybrid structures of nanocups and nanoparticles with ultrasensitivity to refractive index change. In this study, an electrochemical localized surface plasmon resonance (LSPR) sensor was developed by coupling electrochemistry to LSPR spectroscopy measurement on the nanoscale cup arrays (nanoCA). Based on the combination of electrochemistry and LSPR measurement, the electrochemical LSPR on nanoCA was observed with significant resonance wavelength shifts in electrochemical modulation. The synchronous implementation of cyclic voltammetry and optical transmission spectrum can be used to obtain multiply sensing information and investigate the enhancement for LSPR from electrochemical scanning. The electrochemical enhanced LSPR was utilized as biosensor to detect biomolecules. The electrochemical LSPR biosensor with synchronous electrochemical and optical implement showed higher sensitivity than that of conventional optical LSPR measurement. Detecting with multi-transducer parameters and high sensitivity, the electrochemical LSPR provided a promising approach for chemical and biological detection. (C) 2014 Elsevier B.V. All rights reserved.

引用

页码：237 / 242

页数：6

共 34 条

[1] Electrochemical Surface Plasmon Resonance and Waveguide-Enhanced Glucose Biosensing with N-Alkylaminated Polypyrrole/Glucose Oxidase Multilayers [J].