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Low MIB-1 labeling index in anti-HCV positive hepatocellular carcinoma
被引:0
作者:
Watanuki, A
Ohwada, S
Fukusato, T
Kawate, S
Makita, F
Morishita, Y
机构:
[1] Gunma Univ, Sch Med, Dept Surg 2, Gunma 3718511, Japan
[2] Gunma Univ Hosp, Div Diagnost Pathol, Gunma, Japan
[3] Nishi Gunma Hosp, Natl Sanatorium, Gunma 3718511, Japan
关键词:
hepatocellular carcinoma;
anti-HCV antibody;
proliferative activity;
Ki-67;
MIB-1;
argyrophilic nucleolar organizer regions;
p53;
c-myc;
D O I:
暂无
中图分类号:
R73 [肿瘤学];
学科分类号:
100214 ;
摘要:
It has been reported that hepatitis C virus-related hepatocellular carcinoma (HCC) patients survive longer than hepatitis B virus-related patients. In this study, since HCC patients positive for anti-HCV antibody had significantly longer disease-free survival (p<0.05), we evaluated the proliferative activity of 58 resected HCCs and the status of their viral infections. Ki-67 (MIB-1) immunostaining, argyrophilic nucleolar organizer regions and c-myc gene amplification were examined as parameters of proliferation, and p53 overexpression was examined in relation to clinicopathologic features and prognosis. Thirty-nine patients with HCC (67%) were positive for anti-HCV antibody alone, five (9%) were negative for both anti-HCV and HBV antibodies, two (3%) were positive for both anti-HCV and HBV antibodies, and 12 (21%) had HBsAg alone. HCC patients with anti-HCV antibody had a lower MIB-1 labeling index (LI) than HCC patients negative for the antibody (p<0.05), irrespective of the serum HBsAg status. However, there was no significant correlation between anti-HCV antibody and other proliferative parameters. MIB-1 could simply be related to cellular proliferation. On the other hand, the other parameters may be related to tumor progression as well as proliferation. HCV-related HCC does have lower proliferative activity and a better prognosis.
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页码:1017 / 1022
页数:6
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