Loss of Runt-Related Transcription Factor 3 Causes Development and Progression of Hepatocellular Carcinoma

被引：30
|
作者：
Shiraha, Hidenori [1 ]
Nishina, Shin-ichi [1 ]
Yamamoto, Kazuhide [1 ]
机构：
[1] Okayama Univ, Grad Sch Med & Dent, Dept Gastroenterol & Hepatol, Kita Ku, Okayama 7008558, Japan
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2011年 / 112卷 / 03期
关键词：
APOPTOSIS; ANGIOGENESIS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR SUPPRESSOR GENE; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-CELL GROWTH; INHIBITS TUMOR-GROWTH; GENE-EXPRESSION; MULTIPLE GENES; EARLY-STAGE; HYPERMETHYLATION; LIVER; METHYLATION; MUTATIONS;
D O I：
10.1002/jcb.22973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC. J. Cell. Biochem. 112: 745-749,2011. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：745 / 749
页数：5
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