Loss of Runt-Related Transcription Factor 3 Causes Development and Progression of Hepatocellular Carcinoma

被引：30
|
作者：
Shiraha, Hidenori [1 ]
Nishina, Shin-ichi [1 ]
Yamamoto, Kazuhide [1 ]
机构：
[1] Okayama Univ, Grad Sch Med & Dent, Dept Gastroenterol & Hepatol, Kita Ku, Okayama 7008558, Japan
来源：
JOURNAL OF CELLULAR BIOCHEMISTRY | 2011年 / 112卷 / 03期
关键词：
APOPTOSIS; ANGIOGENESIS; EPITHELIAL-MESENCHYMAL TRANSITION; TUMOR SUPPRESSOR GENE; ENDOTHELIAL GROWTH-FACTOR; EPITHELIAL-CELL GROWTH; INHIBITS TUMOR-GROWTH; GENE-EXPRESSION; MULTIPLE GENES; EARLY-STAGE; HYPERMETHYLATION; LIVER; METHYLATION; MUTATIONS;
D O I：
10.1002/jcb.22973
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Runt-related transcription factor 3 (RUNX3) is reported as a tumor suppressor gene for gastric cancer, and may be important in the development of hepatocellular carcinoma (HCC). RUNX3 expression is frequently lost or decreased by hemizygous deletion or hypermethylation of its promoter lesion in HCC. The significance of decreased expression of RUNX3 in HCC has not been fully elucidated, but is likely related to dysfunction of cell cycle regulation, decrement of apoptosis, enhancement of angiogenesis, and development of epithelial mesenchymal transition. RUNX3 is a promising candidate as a tumor suppressor gene for HCC. J. Cell. Biochem. 112: 745-749,2011. (C) 2010 Wiley-Liss, Inc.
引用
收藏
页码：745 / 749
页数：5
相关论文
共 50 条
  • [1] Loss of Runt-Related Transcription Factor 3 Expression Associated with Human Hepatocellular Carcinoma Progression and Prognosis
    Li, Jianguo
    Jiang, Xiaojie
    ASIAN PACIFIC JOURNAL OF CANCER PREVENTION, 2011, 12 (09) : 2285 - 2290
  • [2] Runt-related transcription factor 3 reverses epithelial-mesenchymal transition in hepatocellular carcinoma
    Tanaka, Shigetomi
    Shiraha, Hidenori
    Nakanishi, Yutaka
    Nishina, Shin-Ichi
    Matsubara, Minoru
    Horiguchi, Shigeru
    Takaoka, Nobuyuki
    Iwamuro, Masaya
    Kataoka, Junro
    Kuwaki, Kenji
    Hagihara, Hiroaki
    Toshimori, Junichi
    Ohnishi, Hideki
    Takaki, Akinobu
    Nakamura, Shinichiro
    Nouso, Kazuhiro
    Yagi, Takahito
    Yamamoto, Kazuhide
    INTERNATIONAL JOURNAL OF CANCER, 2012, 131 (11) : 2537 - 2546
  • [3] Runt-Related Transcription Factor 3 Promotes Acute Myeloid Leukemia Progression
    Zhang, Wenwen
    Ma, Qian
    Long, Bing
    Sun, Zhangyi
    Liu, Lingling
    Lin, Dongjun
    Zhao, Minyi
    FRONTIERS IN ONCOLOGY, 2021, 11
  • [4] Expression levels of the runt-related transcription factor 1 and 3 genes in the development of acute myeloid leukemia
    Krygier, Adrian
    Szmajda, Dagmara
    Zebrowska, Marta
    Jelen, Agnieszka
    Balcerczak, Ewa
    ONCOLOGY LETTERS, 2018, 15 (05) : 6733 - 6738
  • [5] Runt-related transcription factor 3 promoter hypermethylation and gastric cancer risk: A meta-analysis
    Mei Lina
    Wu Changan
    Zhao Qing
    OPEN LIFE SCIENCES, 2018, 13 (01): : 64 - 70
  • [6] Detection of deleted in malignant brain tumors 1 and runt-related transcription factor 3 gene expressions in bladder carcinoma
    Dodurga, Yavuz
    Avci, Cigir Biray
    Satiroglu-Tufan, N. Lale
    Tataroglu, Canten
    Kesen, Zehra
    Dogan, Z. Ozlem
    Yilmaz, Sunde
    Gunduz, Cumhur
    MOLECULAR BIOLOGY REPORTS, 2012, 39 (04) : 4691 - 4695
  • [7] Expression and Prognosis Analyses of Runt-Related Transcription Factor Family in Human Leukemia
    Sun, Cheng-Cao
    Li, Shu-Jun
    Chen, Zhen-Long
    Li, Guang
    Zhang, Qian
    Li, De-Jia
    MOLECULAR THERAPY-ONCOLYTICS, 2019, 12 : 103 - 111
  • [8] Runt-Related Transcription Factor 2 (Runx2) Is Responsible for Galectin-3 Overexpression in Human Thyroid Carcinoma
    Kaptan, Engin
    Bas, Serap Sancar
    Sancakli, Aylin
    Aktas, Hatice Gumushan
    Bayrak, Bertan Boran
    Yanardag, Refiye
    Bolkent, Sehnaz
    JOURNAL OF CELLULAR BIOCHEMISTRY, 2017, 118 (11) : 3911 - 3919
  • [9] Repression of Vascular Endothelial Growth Factor Expression by the Runt-Related Transcription Factor 1 in Acute Myeloid Leukemia
    ter Elst, Arja
    Ma, Bin
    Scherpen, Frank J. G.
    de Jonge, Hendrik J. M.
    Douwes, Jenny
    Wierenga, Albertus T. J.
    Schuringa, Jan Jacob
    Kamps, Willem A.
    de Bont, Eveline S. J. M.
    CANCER RESEARCH, 2011, 71 (07) : 2761 - 2771
  • [10] The association between runt-related transcription factor 3 gene promoter methylation and gastric cancer: A meta-analysis
    Liu, Xu
    Wang, Lina
    Guo, Yongtie
    JOURNAL OF CANCER RESEARCH AND THERAPEUTICS, 2016, 12 (05) : 50 - 53
12345