Physiological removal of silicon from bioactive glass

被引：2

作者：

Lai, W ^{[1
]}

Garino, J

Flaitz, CM

Ducheyne, P

机构：

[1] Univ Penn, Dept Bioengn, Philadelphia, PA 19104 USA

[2] Univ Penn, Ctr Bioact Mat & Tissue Eng, Dept Orthopaed Surg, Philadelphia, PA 19104 USA

[3] Univ Texas, Dent Branch, Div Oral & Maxillofacial Pathol, Houston, TX 77030 USA

来源：

BIOCERAMICS | 2000年 / 192-1卷

关键词：

bioactive glass; biodegradation; rabbit; resorption; silica; silicon;

D O I：

10.4028/www.scientific.net/KEM.192-195.581

中图分类号：

TQ174 [陶瓷工业]; TB3 [工程材料学];

学科分类号：

0805 ; 080502 ;

摘要：

Bioactive glass granules were implanted in the paraspinal muscle and tibiae of rabbits in order to determine the pathway of the silicon released from bioactive glass it? vivo. We traced and quantified the silicon released by obtaining 24-hour urine samples, as well as blood samples for up to 7 months after implantation. Furthermore, local muscle and bone tissue as well as the following organs were resected for chemical and histopathological analyses: brain, heart, kidney, liver, lung, lymph nodes, spleen, and thymus. The concentrations of silicon found in the urine were well below saturation and no accumulation of silicon was found in the major organs after silicon excretion had halted. The removal of silicon from the bony matrix was slower overall compared to an intramuscular site, taking a total of 24 weeks versus 19 weeks to complete silicon removal, respectively.

引用

页码：581 / 584

页数：4