ROS: Really involved in oxygen sensing

被引：136

作者：

Kaelin, WG ^{[1
]}

机构：

[1] Harvard Univ, Brigham & Womens Hosp, Sch Med,Howard Hughes Med Inst, Dana Farber Canc Inst, Boston, MA 02115 USA

来源：

CELL METABOLISM | 2005年 / 1卷 / 06期

关键词：

D O I：

10.1016/j.cmet.2005.05.006

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The role of reactive oxygen species (ROS) in the cellular response to cellular oxygen sensing has been controversial. Three papers in this issue of Cell Metabolism (Brunelle et al., 2005; Guzy et al., 2005; Mansfield et al., 2005) used genetic tools to establish that ROS produced by mitochondria are required for the normal induction of HIF (hypoxia-inducible factor), which is a master regulator of oxygen-sensitive gene expression, by low oxygen.

引用

页码：357 / 358

页数：2

共 13 条

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