An arthritogenic alphavirus uses the α1β1 integrin collagen receptor

被引：36

作者：

La Linn, M

Eble, JA

Lübken, C

Slade, RW

Heino, J

Davies, J

Suhrbier, A ^{[1
]}

机构：

[1] PO Royal Brisbane Hosp, Queensland Inst Med Res, Brisbane, Qld 4029, Australia

[2] Australian Ctr Int & Trop Hlth & Nutr, Brisbane, Qld, Australia

[3] Univ Queensland, Brisbane, Qld, Australia

[4] Univ Klinikum Munster, Inst Physiol Chem & Pathobiochem, Munster, Germany

[5] So Cross Univ, Grad Res Coll, Lismore, NSW, Australia

[6] Univ Jyvaskyla, Jyvaskyla, Finland

[7] Alfred Hosp, Melbourne, Vic, Australia

[8] Monash Univ, Melbourne, Vic 3004, Australia

来源：

VIROLOGY | 2005年 / 336卷 / 02期

基金：

英国医学研究理事会;

关键词：

Ross River virus; receptor; alpha; 1; beta; integrin; collagen IV;

D O I：

10.1016/j.virol.2005.03.015

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Ross River (RR) virus is an alphavirus endemic to Australia and New Guinea and is the aetiological agent of epidemic polyarthritis or RR virus disease. Here we provide evidence that RR virus uses the collagen-binding a alpha 1 beta 1 integrin as a cellular receptor. Infection could be inhibited by collagen IV and antibodies specific for the beta 1 and alpha 1 integrin proteins, and fibroblasts from alpha 1-integrin(-/-) mice were less efficiently infected than wild-type fibroblasts. Soluble alpha 1 beta 1 integrin bound immobilized RR virus, and peptides representing the alpha 1 beta 1 integrin binding-site on collagen IV inhibited virus binding to cells. We speculate that two highly conserved regions within the cell-receptor binding domain of E2 mimic collagen and provide access to cellular collagen-binding receptors. (c) 2005 Elsevier Inc. All rights reserved.

引用

页码：229 / 239

页数：11

共 63 条

[1] Interaction of West Nile virus with αvβ3 integrin mediates virus entry into cells [J].