Still entangled: Assembly of the central spindle by multiple microtubule modulators

被引：45

作者：

Douglas, Max E. ^{[1
]}

Mishima, Masanori ^{[1
]}

机构：

[1] Univ Cambridge, Wellcome Trust Canc Res UK Gurdon Inst, Cambridge CB2 1QN, England

来源：

SEMINARS IN CELL & DEVELOPMENTAL BIOLOGY | 2010年 / 21卷 / 09期

基金：

英国生物技术与生命科学研究理事会;

关键词：

Central spindle; Microtubule bundle; MKLP1; CYK4; PRC1; KINESIN-LIKE PROTEIN; GTPASE-ACTIVATING PROTEIN; POLO-LIKE KINASE-1; MITOTIC SPINDLE; AURORA-B; CONTRACTILE RING; HUMAN-CELLS; MAMMALIAN-CELLS; MIDZONE FORMATION; MEIOTIC SPINDLE;

D O I：

10.1016/j.semcdb.2010.08.005

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The central spindle is a microtubule-based structure that assembles during anaphase of mitosis in animal cells and is essential for multiple steps of cytokinesis. Central spindle assembly occurs by the cooperative action of multiple microtubule motors and modulators. Here, we review the mechanism by which the central spindle is formed, the role of several key proteins in this process and how central spindle assembly is temporally and spatially coordinated with mitosis. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：899 / 908

页数：10

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