Molecular evidence of HTLV-1 intrafamilial transmission in a non-endemic area in Argentina

被引：14
作者：
Gastaldello, R
Otsuki, K
Barbas, MG
Vicente, ACP
Gallego, S
机构：
[1] Natl Univ Cordoba, Sch Med, Inst Virol, Lab Human Lymphotrop Viruses, RA-5016 Cordoba, Argentina
[2] Inst Oswaldo Cruz, Lab Mol Genet Microorganisms, BR-20001 Rio De Janeiro, Brazil
来源：
JOURNAL OF MEDICAL VIROLOGY | 2005年 / 76卷 / 03期
关键词：
HTLV-1; intrafamilial transmission; Argentina; molecular evidence;
D O I：
10.1002/jmv.20370
中图分类号：
Q93 [微生物学];
学科分类号：
071005 ; 100705 ;
摘要：
In the North of Argentina, an endemic area for HTLV-1, intrafamilial transmission of this virus has been observed. The HTLV-1 status in 13 family members of a seropositive blood donor from the central region of Argentina (non-endemic area) was investigated. According to serological and molecular assays, four members of this family (the blood donor, the husband, a son, and a daughter-in-law) proved to be HTLV-1 positive. LTR, tax, and env sequences from the provirus infecting the family members were identical. This strongly suggests the intrafamilial transmission of the virus. This study demonstrated intrafamilial transmission of HTLV-1 in a non-endemic area of Argentina. (C) 2005 Wiley-Liss, Inc
引用
收藏
页码：386 / 390
页数：5
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