Photodynamic Therapy Application of PAMAM-Porphyrin Molecule on Stomach Cancer Cells

被引：1

作者：

Kiris, Tugba ^{[1
]}

Burgucu, Mehmet Necmi ^{[1
]}

Sagir, Tugba ^{[2
]}

Senel, Mehmet ^{[3
]}

Isik, Sevim ^{[2
]}

Ates, Gamze Bolukbasi ^{[4
]}

Tabakoglu, Hasim Ozgur ^{[1
]}

机构：

[1] Fatih Univ, Inst Biomed Engn, Istanbul, Turkey

[2] Fatih Univ, Dept Biol, Istanbul, Turkey

[3] Fatih Univ, Dept Chem, Istanbul, Turkey

[4] Bogazici Univ, Inst Biomed Engn, Istanbul, Turkey

来源：

OPTICAL METHODS FOR TUMOR TREATMENT AND DETECTION: MECHANISMS AND TECHNIQUES IN PHOTODYNAMIC THERAPY XXIV | 2015年 / 9308卷

关键词：

Photodynamic theraphy; PpIX; PAMAM; AGS; LIGHT-SOURCES; PDT;

D O I：

10.1117/12.2082731

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

In this study, effect of a novel LED-based light source developed for 96-well-plates cell culture applications, was tried on AGS stomach cancer cell line, in combination with Poly(amido amine) (PAMAM) modified - porhyrin molecule. For each 4 generation of modified PpIX molecule 5 different concentrations were tried. According to results PAMAM molecule did not show photosensitizer property also didn't show any toxic effect even if higher concentrations. Morphology and real time monitoring analysis results supported each other and confirmed that, PpIX molecules with and without modificated high concentrations (> 100 mu M) caused cell death via toxicicity. Optimal concentrations for PAMAM modified Pp-IX was found 50 mu M and 100 mu M.

引用

页数：6

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