Enzymatic degradation of block copolymers obtained by sequential ring opening polymerization of L-lactide and ε-caprolactone

被引：53
作者：
Zhao, Zhenxian
Yang, Liu
Hu, Yanfei
He, Yong
Wei, Jia [1 ]
Li, Suming
机构：
[1] Fudan Univ, Dept Mat Sci, Shanghai 200433, Peoples R China
[2] Univ Montpellier I, Fac Pharm, Max Mousseron Inst Biomol, CRBA, F-34060 Montpellier, France
来源：
POLYMER DEGRADATION AND STABILITY | 2007年 / 92卷 / 10期
关键词：
enzymatic degradation; block copolymer; poly(L-lactide); poly(epsilon-caprolactone);
D O I：
10.1016/j.polymdegradstab.2007.07.012
中图分类号：
O63 [高分子化学（高聚物）];
学科分类号：
070305 ; 080501 ; 081704 ;
摘要：
Copolymers of a-caprolactone and L-lactide with different molar ratios were prepared via sequential ring opening polymerization (ROP) of both monomers. The resulting PCL-PLLA-PCL triblock copolymers were characterized by using NMR, SEC, DSC and XRD. One melting peak corresponding to the PCL block was detected, but the presence of PLLA decreased the crystallinity of PCL. Enzyme-catalyzed biodegradation of solution cast films was investigated at 37 C in the presence of Pseudomonas lipase. It was observed that the PLLA component retarded the degradation of the block copolymer as compared to the PCL homopolymer. Therefore, the enzymatic degradation rate can be adjusted by varying the composition of the copolymers. H-1 NMR and SEC data showed no significant chemical composition or molecular weight changes during degradation, indicating that the degradation proceeded according to a surface erosion mechanism. ESEM confirmed surface erosion with appearance of a rugged morphology. (C) 2007 Elsevier Ltd. All rights reserved.
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收藏
页码：1769 / 1777
页数：9
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