Stable analogues of Aminoacyl-tRNA for inhibition of an essential step of bacterial cell-wall synthesis

被引：27

作者：

Chemama, Maryline

Fonvielle, Matthieu

Villet, Regis

Arthur, Michel

Valery, Jean-Marc

Etheve-Quelquejeu, Melanie

机构：

[1] Univ Paris 06, CNRS, UMR 7613, Paris, France

[2] INSERM, LRMA, Ctr Rech Cordeliers, U8722,Equipe 12, F-75006 Paris, France

[3] Univ Paris 06, UMR S 872, F-75006 Paris, France

[4] Univ Paris 05, UMR S 872, F-75006 Paris, France

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2007年 / 129卷 / 42期

关键词：

D O I：

10.1021/ja0749946

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A stable analogue of Ala-tRNAAla containing 1,2,4 oxadiazole as a mime of the 3' amino acyl ester was synthesized and showed to inhibit FemX(wv), IC50 = 1.4 M-mu), an alanyl transferase essential to form the peptidoglycan network of Gram-positive bacteria] pathogens. The oxadiazole ring is a good candidate for design of nucleotide analogues which may be applicable to important targets including amino acyl-tRNA synthetases and the ribosomal peptidyl-transferase center.

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页码：12642 / +

页数：3

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