The Interplay of the Extracellular Matrix and Stromal Cells as a Drug Target in Stroma-Rich Cancers

被引：54

作者：

Kozlova, Nina ^{[1
,2
]}

Grossman, Joseph E. ^{[1
,2
]}

Iwanicki, Marcin P. ^{[3
]}

Muranen, Taru ^{[1
,2
]}

机构：

[1] Beth Israel Deaconess Med Ctr, Dept Med, Boston, MA 02215 USA

[2] Harvard Med Sch, Boston, MA 02115 USA

[3] Stevens Inst Technol, Chem & Chem Biol, Hoboken, NJ 07030 USA

来源：

TRENDS IN PHARMACOLOGICAL SCIENCES | 2020年 / 41卷 / 03期

关键词：

ANGIOTENSIN RECEPTOR BLOCKER; TUMOR-ASSOCIATED MACROPHAGES; HYPOXIA-INDUCIBLE FACTOR-1; VITAMIN-D-RECEPTOR; ADIPOSE-TISSUE; TGF-BETA; RESISTANCE; SURVIVAL; MICROENVIRONMENT; FIBROBLASTS;

D O I：

10.1016/j.tips.2020.01.001

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

The tumor microenvironment (TME) is a complex neighborhood that consists of immune cells, fibroblasts, pericytes, adipocytes, endothelial and neuronal cells, and the extracellular matrix proteins. TME also consists of physical factors, such as oxygen availability, changing pH, interstitial fluid pressure, and tissue stiffness. As cancer progresses, the physical properties and the cells in the TME change significantly, impacting the efficacy of the therapies and modulating drug resistance. This has led to the development of several new treatments targeting the TME. This review focuses on recent advances on the role of TME in drug resistance, with a particular focus on the ongoing clinical trials aiming at disrupting the TME- and the extracellular matrix-mediated protection against therapies.

引用

页码：183 / 198

页数：16

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