An Efficient Synthesis of 7-(Arylmethyl)-3-tert-butyl-1-phenyl-6,7-dihydro-1H,4H-pyrazolo[3,4-d][1,3]oxazines

被引：25
|
作者：
Abonia, Rodrigo [1 ]
Castillo, Juan [1 ]
Insuasty, Braulio [1 ]
Quiroga, Jairo [1 ]
Nogueras, Manuel [2 ]
Cobo, Justo [2 ]
机构：
[1] Univ Valle, Dept Quim, Cali 25360, Colombia
[2] Univ Jaen, Dept Quim Inorgan & Organ, Jaen 23071, Spain
来源：
EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 33期
关键词：
5-Aminopyrazoles; Etherification; Pyrazolo-oxazines; Heterocycles; Cyclization; Fused-ring systems; DERIVATIVES;
D O I：
10.1002/ejoc.201000678
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
An efficient and three-step procedure for the synthesis of novel 6,7-dihydro-1H,4H-pyrazolo[3,4 -d][1,3]oxazine derivatives in good to excellent yields by treatment of pyrazol-amines with aqueous formaldehyde in the presence of acetic acid is provided. The reactions proceeded through an intramolecular etherification process by dehydration of a 1,5-diol intermediate formed in the course of the reaction and promoted by acid media.
引用
收藏
页码：6454 / 6463
页数：10
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