An Efficient Synthesis of 7-(Arylmethyl)-3-tert-butyl-1-phenyl-6,7-dihydro-1H,4H-pyrazolo[3,4-d][1,3]oxazines

被引：25

作者：

Abonia, Rodrigo ^{[1
]}

Castillo, Juan ^{[1
]}

Insuasty, Braulio ^{[1
]}

Quiroga, Jairo ^{[1
]}

Nogueras, Manuel ^{[2
]}

Cobo, Justo ^{[2
]}

机构：

[1] Univ Valle, Dept Quim, Cali 25360, Colombia

[2] Univ Jaen, Dept Quim Inorgan & Organ, Jaen 23071, Spain

来源：

EUROPEAN JOURNAL OF ORGANIC CHEMISTRY | 2010年 / 2010卷 / 33期

关键词：

5-Aminopyrazoles; Etherification; Pyrazolo-oxazines; Heterocycles; Cyclization; Fused-ring systems; DERIVATIVES;

D O I：

10.1002/ejoc.201000678

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

An efficient and three-step procedure for the synthesis of novel 6,7-dihydro-1H,4H-pyrazolo[3,4 -d][1,3]oxazine derivatives in good to excellent yields by treatment of pyrazol-amines with aqueous formaldehyde in the presence of acetic acid is provided. The reactions proceeded through an intramolecular etherification process by dehydration of a 1,5-diol intermediate formed in the course of the reaction and promoted by acid media.

引用

页码：6454 / 6463

页数：10

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