The BCY3/BCC 2017 survey on physicians' knowledge, attitudes and practice towards fertility and pregnancy-related issues in young breast cancer patients

被引：71

作者：

Lambertini, Matteo ^{[1
,2
,3
]}

Di Maio, Massimo ^{[4
]}

Pagani, Olivia ^{[5
,6
]}

Curigliano, Giuseppe ^{[7
]}

Poggio, Francesca ^{[1
,2
,3
,8
,9
]}

Del Mastro, Lucia ^{[8
,9
]}

Paluch-Shimon, Shani ^{[10
]}

Loibl, Sibylle ^{[11
,12
]}

Partridge, Ann H. ^{[13
]}

Demeestere, Isabelle ^{[14
,15
]}

Azim, Hatem A., Jr. ^{[16
]}

Peccatori, Fedro A. ^{[17
]}

机构：

[1] Inst Jules Bordet, Dept Med Oncol, 1 Rue Heger Bordet, B-1000 Brussels, Belgium

[2] Inst Jules Bordet, Breast Canc Translat Res Lab, 1 Rue Heger Bordet, B-1000 Brussels, Belgium

[3] ULB, 1 Rue Heger Bordet, B-1000 Brussels, Belgium

[4] Univ Turin, Dept Oncol, AO Ordine Mauriziano, Med Oncol, Turin, Italy

[5] Geneva Univ Hosp, Swiss Grp Clin Canc Res SAKK, Breast Unit, Lugano Viganello, Switzerland

[6] Geneva Univ Hosp, Swiss Grp Clin Canc Res SAKK, Inst Oncol Southern Switzerland IOSI, Lugano Viganello, Switzerland

[7] Univ Milan, Dept Oncol & Hematooncol, New Drugs & Early Drug Dev Innovat Therapies, European Inst Oncol,IRCCS European Sch Oncol ESO, Milan, Italy

[8] Univ Genoa, Sch Med, Policlin San Martino IST, Dept Med Oncol,UO Sviluppo Terapie Innovat, Genoa, Italy

[9] Univ Genoa, Sch Med, Dept Internal Med & Med Specialties DIMI, Genoa, Italy

[10] Shaare Zedek Med Ctr, Dept Oncol, Jerusalem, Israel

[11] GBG, Neu Isenburg, Germany

[12] Ctr Haematol & Oncol, Frankfurt, Germany

[13] Dana Farber Canc Inst, Dept Med Oncol, Boston, MA 02115 USA

[14] CUB Erasme, Res Lab Human Reprod, Fertil Clin, Brussels, Belgium

[15] ULB, Brussels, Belgium

[16] AUB, Div Hematol Oncol, Dept Med, Beirut, Lebanon

[17] IRCCS European Inst Oncol, ESO, Gynecol Oncol Dept, Fertil & Procreat Unit, Milan, Italy

来源：

BREAST | 2018年 / 42卷

关键词：

Breast cancer; Young patients; Fertility; Pregnancy; PRESERVE OVARIAN-FUNCTION; LONG-TERM SAFETY; OF-THE-ART; WOMEN; CHEMOTHERAPY; STIMULATION; CRYOPRESERVATION; METAANALYSIS; STRATEGIES; RECOMMENDATIONS;

D O I：

10.1016/j.breast.2018.08.099

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Background: Fertility and pregnancy-related issues are major concerns for young breast cancer patients. Limited data are available on physicians' knowledge, attitudes and practice in these fields. Methods: A 26-item questionnaire exploring 3 different topics (fertility preservation, pregnancy after breast cancer and breast cancer during pregnancy) was sent by email to physicians attending the 2016 3rd European School of Oncology (ESO) - European Society for Medical Oncology (ESMO) Breast Cancer in Young Women Conference (BCY3) and the 15th St. Gallen International Breast Cancer Conference 2017 (BCC 2017). Given the selected sample, survey respondents were expected to have a higher than average interest in the management of breast cancer patients. Descriptive analyses were performed. Results: A total of 273 physicians (105 at BCY3 and 168 at BCC 2017) completed the survey; 37.0%, 46.9% and 34.8% reported never having consulted the available international guidelines on fertility preservation, pregnancy after breast cancer and management of breast cancer during pregnancy, respectively. Up to 18.3% of respondents did not know if the different fertility preservation options were available in their country; 22.3% suggested that controlled ovarian stimulation should not be considered safe in patients with hormone receptor-positive disease. A total of 30.4% of respondents agreed or were neutral on the statement that pregnancy in breast cancer survivors may increase the risk of recurrence. Regarding breast cancer during pregnancy, 23.8% and 38.1% disagreed or were neutral on the statements that endocrine therapy and anti-HER2 agents should be avoided during pregnancy, respectively. Conclusions: Further educational initiatives are needed to improve physicians' knowledge and adherence to available guidelines when addressing fertility and pregnancy-related issues in young breast cancer patients. (C) 2018 Elsevier Ltd. All rights reserved.

引用

页码：41 / 49

页数：9

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