Progressive Multifocal Leukoencephalopathy

被引：23

作者：

Grebenciucova, Elena ^{[1
]}

Berger, Joseph R. ^{[2
]}

机构：

[1] Northwestern Univ, Feinberg Sch Med, Davee Dept Neurol, Multiple Sclerosis Div, 675 St Clair, Chicago, IL 60611 USA

[2] Univ Penn, Multiple Sclerosis Div, Dept Neurol, Perelman Sch Med, 3400 Convent Ave, Philadelphia, PA 19104 USA

来源：

NEUROLOGIC CLINICS | 2018年 / 36卷 / 04期

关键词：

John Cunningham virus; Progressive multifocal leukoencephalopathy; Opportunistic infection; RECONSTITUTION INFLAMMATORY SYNDROME; VIRUS-ANTIBODY LEVELS; JC VIRUS; MULTIPLE-SCLEROSIS; IMMUNE RECONSTITUTION; TREATED PATIENTS; RISK; DISEASE; PLASMA; COMPLICATIONS;

D O I：

10.1016/j.ncl.2018.06.002

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Progressive multifocal leukoencephalopathy (PML) is a rare opportunistic infection that occurs in patients whose immune system is compromised either because of an underlying illness or an immunosuppressive medication. John Cunningham virus, prevalent in 60% or more of the adult population as a latent or persistent infection, is responsible for the syndrome of PML. This article reviews PML in association with the most common immunotherapies and discusses risk mitigation and monitoring strategies.

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页码：739 / +

页数：13

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