Human Astrovirus VA1 Encephalitis in Pediatric Patients With Cancer: Report of 2 Cases and Review of the Literature

被引：10

作者：

Bami, Sakshi ^{[1
]}

Hidinger, Jennifer ^{[2
]}

Madni, Arshia ^{[1
,3
]}

Hargest, Virginia ^{[2
]}

Schultz-Cherry, Stacey ^{[2
]}

Cortez, Valerie ^{[4
]}

Cross, Shane J. ^{[5
]}

Ward, Deborah A. ^{[5
]}

Hayden, Randall T. ^{[6
]}

Rubnitz, Jeffrey ^{[7
]}

Pui, Ching-Hon ^{[7
]}

Khan, Raja B. ^{[8
]}

Hijano, Diego R. ^{[2
]}

机构：

[1] St Jude Childrens Res Hosp, Hospitalist Med Program, Memphis, TN 38105 USA

[2] St Jude Childrens Res Hosp, Dept Infect Dis, Memphis, TN 38105 USA

[3] St Jude Childrens Res Hosp, Div Qual Life & Palliat Care, Memphis, TN 38105 USA

[4] Univ Calif Santa Cruz, Dept Mol & Cell Dev Biol, Santa Cruz, CA 95064 USA

[5] St Jude Childrens Res Hosp, Dept Pharmaceut Sci, Memphis, TN 38105 USA

[6] St Jude Childrens Res Hosp, Dept Pathol, Memphis, TN 38105 USA

[7] St Jude Childrens Res Hosp, Dept Oncol, Memphis, TN 38105 USA

[8] St Jude Childrens Res Hosp, Div Neurol, Memphis, TN 38105 USA

来源：

JOURNAL OF THE PEDIATRIC INFECTIOUS DISEASES SOCIETY | 2022年 / 11卷 / 09期

关键词：

astrovirus; cancer; children; encephalitis; VA1; INFECTION; VA1/HMO-C; DIAGNOSIS;

D O I：

10.1093/jpids/piac045

中图分类号：

R51 [传染病];

学科分类号：

100401 ;

摘要：

Novel human astroviruses (HAstVs) have recently been implicated as rare causes of fatal encephalitis in immunocompromised patients, for which there is no proven treatment. We report 2 cases from our institution in which HAstV-VA1 was detected in the cerebrospinal fluid by metagenomic next-generation sequencing after the initial evaluation revealed no etiology. We report two children with HAstV-VA1 encephalitis detected by metagenomic next-generation sequencing. Although rare, awareness of this emerging pathogen as a cause of encephalitis in immunocompromised children is critical, given the associated poor prognosis.

引用

页码：408 / 412

页数：5

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