New benzo[g]isoquinoline-5,10-diones and dihydrothieno [2,3-b]naphtho-4,9-dione derivatives:: Synthesis and biological evaluation as potential antitumoral agents

被引：37
作者：
Gomez-Monterrey, I
Campiglia, P
Grieco, P
Diurno, MV
Bolognese, A
La Colla, P
Novellino, E [1 ]
机构：
[1] Univ Naples Federico II, Dipartimento Chim Farmaceut & Tossicol, Naples, Italy
[2] Univ Cagliari, Dipartimento Biol Sperimentale, Sez Microbiol, I-09124 Cagliari, Italy
[3] Univ Naples Federico II, Dipartimento Chim Organ & Biol, Naples, Italy
来源：
BIOORGANIC & MEDICINAL CHEMISTRY | 2003年 / 11卷 / 17期
关键词：
D O I：
10.1016/S0968-0896(03)00310-9
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Novel antitumoral agents with quinonic structure were synthesized and evaluated for their in vitro cytotoxic activities. This study examines the cytotoxic activities of several aryl benzo[g]isoquinoline-5,10-dione derivatives and a number of aminoacyl dihydrothieno[2,3-b]naphtho-4.9-dione (DTNQ) derivatives containing amino acids in position 3 of the ring system. Compound 6 showed remarkable cytotoxic activity at submicromolar concentration not only against several human leukaemia and solid tumour cell lines, but also toward sensitive and resistant human cell lines. (C) 2003 Elsevier Ltd. All rights reserved.
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页码：3769 / 3775
页数：7
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