An arabinogalactan with anti-ulcer protective effects isolated from Cereus peruvianus

被引：39

作者：

Abe Tanaka, Leonardo Yugo ^{[3
]}

de Oliveira, Arildo Jose Braz ^{[3
]}

Goncalves, Jose Eduardo ^{[2
]}

Cipriani, Thales Ricardo ^{[1
]}

de Souzac, Lauro Mera ^{[1
]}

Andrade Marques, Maria Consuelo ^{[4
]}

de Paula Wernerd, Maria Fernanda ^{[4
]}

Baggio, Cristiane Hatsuko ^{[4
]}

James Gorine, Philip Albert ^{[1
]}

Sassaki, Guilherme Lanzi ^{[1
]}

Iacomini, Marcello ^{[1
]}

机构：

[1] Univ Fed Parana, Dept Bioquim & Biol Mol, BR-19046 Curitiba, PR, Brazil

[2] CESUMAR, Ctr Univ Maringa, BR-87020900 Maringa, PR, Brazil

[3] Univ Estadual Maringa, Dept Farm & Farmacol, BR-87020900 Maringa, PR, Brazil

[4] Univ Fed Parana, Dept Farmacol, BR-19031 Curitiba, PR, Brazil

来源：

CARBOHYDRATE POLYMERS | 2010年 / 82卷 / 03期

关键词：

Cereus peruvianus; Cactaceae; Arabinogalactan; Anti-ulcer activity; STRUCTURAL-CHARACTERIZATION; MASS-SPECTROMETRY; RHAMNOGALACTURONAN; FEATURES; SPECTRA; LEAVES; MS;

D O I：

10.1016/j.carbpol.2010.05.043

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

A type I arabinogalactan (CPP) was isolated from the viscous gum exuded by Cereus peruvinus (Cactaceae). It contained arabinose. galactose, galacturonic acid, and rhamnose in a 15:66:6:13 molar ratio and had 9 x 10(5) g mol(-1). Methylation analysis and C-13 NMR spectroscopy indicated that CPP is composed of a (1 --> 4)-linked beta-D-Galp main-chain with substituents of alpha-L-Araf at O-2, O-3 and O-6, which are in turn substituted at O-2, O-3, and O-2,3. These are probably linked to O-4 of some rhamnosyl units of a type I rhamnogalacturonan (RG1). The main chain is formed by repeating (1 --> 4)-alpha-D-GalpA-(1 --> 2)-alpha-L-Rhap groups. The methylation analysis suggested the presence of (1 --> 3)-linked beta-Galp structures, perhaps linked to the (1--> 4)-linked beta-D-Galp backbone. CPP significantly inhibited ethanol-induced gastric lesions in rats at an ED50 of 49 mg kg(-1), indicating that it has a gastroprotective effect. The gastric lesion inhibition by CPP suggests a potential use of this polysaccharide, or the crude plant extract, in phytotherapy. (C) 2010 Elsevier Ltd. All rights reserved.

引用

页码：714 / 721

页数：8

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