Viral Serine/Threonine Protein Kinases

被引：106

作者：

Jacob, Thary ^{[1
]}

Van den Broeke, Celine ^{[1
]}

Favoreel, Herman W. ^{[1
]}

机构：

[1] Univ Ghent, Fac Vet Med, Dept Virol Parasitol & Immunol, B-9000 Ghent, Belgium

来源：

JOURNAL OF VIROLOGY | 2011年 / 85卷 / 03期

关键词：

HERPES-SIMPLEX-VIRUS; VARICELLA-ZOSTER-VIRUS; CYTOMEGALOVIRUS UL97 PROTEIN; NUCLEAR POLYHEDROSIS-VIRUS; TEMPERATURE-SENSITIVE MUTANTS; ELONGATION-FACTOR; 1-DELTA; MAREKS-DISEASE VIRUS; RNA-POLYMERASE-II; INFECTING PLODIA-INTERPUNCTELLA; CONFER GANCICLOVIR SENSITIVITY;

D O I：

10.1128/JVI.01369-10

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Phosphorylation represents one the most abundant and important posttranslational modifications of proteins, including viral proteins. Virus-encoded serine/threonine protein kinases appear to be a feature that is unique to large DNA viruses. Although the importance of these kinases for virus replication in cell culture is variable, they invariably play important roles in virus virulence. The current review provides an overview of the different viral serine/threonine protein kinases of several large DNA viruses and discusses their function, importance, and potential as antiviral drug targets.

引用

页码：1158 / 1173

页数：16

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