Hydrolytic microneedles as transdermal drug delivery system

被引：0

作者：

Miyano, T. ^{[1
]}

Miyachi, T. ^{[1
]}

Okanishi, T. ^{[1
]}

Todo, H. ^{[2
]}

Sugibayashi, K. ^{[2
]}

Uernura, T. ^{[1
]}

Takano, N. ^{[1
]}

Konishi, S. ^{[1
]}

机构：

[1] Ritsumeikan Univ, Dept Micro Syst Technol, Kusastu, Japan

[2] Josai Univ, Dept Pharmacokinet & Biopharmaceut, Sakado, Saitama, Japan

来源：

TRANSDUCERS '07 & EUROSENSORS XXI, DIGEST OF TECHNICAL PAPERS, VOLS 1 AND 2 | 2007年

关键词：

drug delivery system; microneedle; bio-degradable; hydrolytic;

D O I：

暂无

中图分类号：

TM [电工技术]; TN [电子技术、通信技术];

学科分类号：

0808 ; 0809 ;

摘要：

We developed hydrolytic microneedles as a transdermal drug delivery system to overcome the shortcomings of existing microneedle-systems: long-term stay of broken needles in the skin and high cost for safe disposal of used needles. The present microneedles spontaneously dissolve by hydrolysis in human skin as well as in the (boiled) water. We verified their basic utility through experiments.

引用

页数：2

共 9 条

[1] Transdermal delivery of desmopressin using a coated microneedle array patch system [J].

Cormier, M ;

Johnson, B ;

Ameri, M ;

Nyam, K ;

Libiran, L ;

Zhang, DD ;

Daddona, P .

JOURNAL OF CONTROLLED RELEASE, 2004, 97 (03) :503-511

[2] Preparation and characterization of biodegradable nanoparticles entrapping immunodominant peptide conjugated with PEG for oral tolerance induction [J].

Lee, WK ;

Park, JY ;

Jung, S ;

Yang, CW ;

Kim, WU ;

Kim, HY ;

Park, JH ;

Park, JS .

JOURNAL OF CONTROLLED RELEASE, 2005, 105 (1-2) :77-88

[3] Mechanism of fluid infusion during microneedle insertion and retraction [J].

Martanto, Wijaya ;

Moore, Jason S. ;

Couse, Tracey ;

Prausnitz, Mark R. .

JOURNAL OF CONTROLLED RELEASE, 2006, 112 (03) :357-361

[4] Microfabricated microneedles for gene and drug delivery [J].

McAllister, DV ;

Allen, MG ;

Prausnitz, MR .

ANNUAL REVIEW OF BIOMEDICAL ENGINEERING, 2000, 2 :289-313

[5] Microfabricated needles for transdermal delivery of macromolecules and nanoparticles: Fabrication methods and transport studies [J].

McAllister, DV ;

Wang, PM ;

Davis, SP ;

Park, JH ;

Canatella, PJ ;

Allen, MG ;

Prausnitz, MR .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2003, 100 (24) :13755-13760

[6] Sugar micro needles as transdermic drug delivery system [J].

Miyano, T ;

Tobinaga, Y ;

Kanno, T ;

Matsuzaki, Y ;

Takeda, H ;

Wakui, M ;

Hanada, K .

BIOMEDICAL MICRODEVICES, 2005, 7 (03) :185-188

[7] Biodegradable polymer microneedles: Fabrication, mechanics and transdermal drug delivery [J].

Park, JH ;

Allen, MG ;

Prausnitz, MR .

JOURNAL OF CONTROLLED RELEASE, 2005, 104 (01) :51-66

[8]

Watanabe T., 2001, AATEX, V8, P15

[9]

Watanabe T., 2001, ALTERN ANIM TEST EXP, V8, P1

← 1 →