Systemic manifestations and liver disease in patients with chronic hepatitis C and type II or III mixed cryoglobulinaemia

被引:61
作者
Donada, C
Crucitti, A
Donadon, V
Tommasi, L
Zanette, G
Crovatto, M
Santini, GF
Chemello, L
Alberti, A
机构
[1] Pordenone Hosp, Lab Immunol Virol & Microbiol, I-33170 Pordenone, Italy
[2] Univ Padua, Dept Internal Med, I-35100 Padova, Italy
关键词
extrahepatic manifestations of HCV; HCV chronic infection; mixed cryoglobulinaemia;
D O I
10.1046/j.1365-2893.1998.00097.x
中图分类号
R57 [消化系及腹部疾病];
学科分类号
摘要
The aim of this study was to evaluate the prevalence of cryoglobulins in patients with chronic hepatitis B and C virus infection and to investigate the association of type II and type III mixed cryoglobulinaemia with systemic manifestations and liver disease stage and outcome in hepatitis C virus (HCV)-positive patients. We analysed the prevalence of cryoglobulinaemia in a cohort of patients with chronic liver disease and compared the systemic manifestations and liver involvement in HCV-positive patients with type II or type III mixed cryoglobulinaemia. The prevalence of serum cryoglobulins was significantly higher in HCV-positive patients than in hepatitis B surface antigen (HBsAg)-positive patients (55.4 vs 20.6%). In HCV-positive patients, stage of liver disease correlated with the prevalence of cryoglobulinaemia. Patients with type IT cryoglobulins showed a significantly higher risk of cirrhosis and of extrahepatic manifestations while patients with type III cryoglobulins had a significantly higher prevalence of hepatocellular carcinoma. During follow-up the former had an odds ratio of 11.9 of death from extrahepatic complications while the latter had an odds ratio of 3.4 of dying from hepatic disease. Our study confirms the high frequency of mixed cryoglobulinaemia in patients with chronic hepatitis C virus infection. The presence and type of cryoglobulins seem to be associated with different clinical manifestations and outcome.
引用
收藏
页码:179 / 185
页数:7
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