Reversal of age-related deficits in object recognition memory in rats with L-deprenyl

被引：82
作者：
de Lima, MN
Laranja, DC
Caldana, F
Bromberg, E
Roesler, R
Schröder, N
机构：
[1] Pontificia Cathlic Univ, Biosci Fac, Dept Physiol Sci, Memory & Neurodegenerat Lab, BR-90619900 Porto Alegre, RS, Brazil
[2] Pontificia Univ Catolica Chile, Sao Lucas Hosp, Inst Gerontol & Geriatr, Grad Program Biomed Gerontol, BR-90619900 Porto Alegre, RS, Brazil
[3] Univ Fed Rio Grande do Sul, Inst Basic Hlth Sci, Dept Pharmacol, Preclin Neuropharmacol Res Grp, BR-90046900 Porto Alegre, RS, Brazil
[4] Univ Fed Rio Grande do Sul, Ctr Biotechnol, BR-91501970 Porto Alegre, RS, Brazil
来源：
EXPERIMENTAL GERONTOLOGY | 2005年 / 40卷 / 06期
关键词：
L-deprenyl; selegifine; novel object recognition; memory; aging;
D O I：
10.1016/j.exger.2005.03.004
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
The monoamine-oxidase-B (MAO-B) inhibitor L-deprenyl (selegiline) is effective in treating Parkinson's disease and possibly cognitive deficits associated with aging, Alzheimer's disease and HIV dementia. The aim of the present study was to investigate the effects of L-deprenyl on short- and long-term recognition memory in aged rats. Young adult and aged male Wistar rats were trained in a novel object recognition task. Retention test trials were carried out at 1.5 or 24 It after training. Aged rats showed impaired recognition memory retention 24 h after training when compared to young animals. Treatment with a daily systemic injection Of L-deprenyl (1.0 mg/kg) for 21 days reversed the memory impairment. A control experiment indicated that L-deprenyl did not affect sensorimotor functions. The results suggest that L-deprenyl reverses age-related deficits in long-term recognition memory. (c) 2005 Elsevier Inc. All rights reserved.
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收藏
页码：506 / 511
页数：6
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