The bioprinting roadmap

被引：324

作者：

Sun, Wei ^{[1
,2
]}

Starly, Binil ^{[3
]}

Daly, Andrew C. ^{[4
]}

Burdick, Jason A. ^{[4
]}

Groll, Juergen ^{[5
]}

Skeldon, Gregor ^{[6
,7
]}

Shu, Wenmiao ^{[8
]}

Sakai, Yasuyuki ^{[9
]}

Shinohara, Marie ^{[9
]}

Nishikawa, Masaki ^{[9
]}

Jang, Jinah ^{[10
]}

Cho, Dong-Woo ^{[10
]}

Nie, Minghao ^{[11
]}

Takeuchi, Shoji ^{[11
,23
]}

Ostrovidov, Serge ^{[21
,22
]}

Khademhosseini, Ali ^{[12
,18
,19
,20
]}

Kamm, Roger D. ^{[13
]}

Mironov, Vladimir ^{[14
,15
]}

Moroni, Lorenzo ^{[16
]}

Ozbolat, Ibrahim T. ^{[17
]}

机构：

[1] Drexel Univ, Coll Engn, Dept Mech Engn & Mech, 3141 Chestnut St, Philadelphia, PA 19104 USA

[2] Tsinghua Univ, Dept Mech Engn, Beijing 100084, Peoples R China

[3] North Carolina State Univ, Comparat Med Inst, Edward P Fitts Dept Ind & Syst Engn, Raleigh, NC 27695 USA

[4] Univ Penn, Dept Bioengn, 210 South 33rd St,Suite 240,Skirkanich Hall, Philadelphia, PA 19104 USA

[5] Univ Wurzburg, Univ Klinikum Wurzburg, Dept Funct Mat Med & Dent, Pleicherwall 2, D-97070 Wurzburg, Germany

[6] Univ Strathclyde, Dept Biomed Engn, Glasgow G4 0NW, Lanark, Scotland

[7] Heriot Watt Univ, Sch Engn & Phys Sci, Edinburgh EH14 4AS, Midlothian, Scotland

[8] Univ Strathclyde, Dept Biomed Engn, Glasgow G4 0NW, Lanark, Scotland

[9] Univ Tokyo, Grad Sch Engn, Dept Chem Engn, Bunkyo Ku, 7-3-1 Hongo, Tokyo 1138656, Japan

[10] Pohang Univ Sci & Technol POSTECH, Dept Creat IT Engn, 77 Cheongam Ro,C5 Bldg,Room 204, Pohang 37673, Kyungbuk, South Korea

[11] Univ Tokyo, Grad Sch Informat Sci & Technol, Dept Mechano Informat, Tokyo, Japan

[12] Univ Calif Los Angeles, Dept Chem & Biomol Engn, 420 Westwood Plaza, Los Angeles, CA 90095 USA

[13] MIT, Mechanobiol Lab, 500 Technol Sq,MIT Bldg,Room NE47-318, Cambridge, MA 02139 USA

[14] 3D Bioprinting Solut, Kashirskoye Shosse 68,Bld 2, Moscow 115409, Russia

[15] Sechenov Moscow Med Univ, Inst Regenerat Med, Trubetskaya Str 8-2, Moscow 119992, Russia

[16] Maastricht Univ, Complex Tissue Regenerat Dept, MERLN Inst Technol Inspired Regenerat Med, Univ Singel 40 3rd Floor,Room C3-577, NL-6229 ER Maastricht, Netherlands

[17] Penn State Univ, Engn Sci & Mech Dept, University Pk, PA 16802 USA

[18] Univ Calif Los Angeles, Dept Bioengn, 410 Westwood Plaza, Los Angeles, CA 90095 USA

[19] Univ Calif Los Angeles, Calif NanoSyt Inst CNSI, 570 Westwood Plaza, Los Angeles, CA 90095 USA

[20] Univ Calif Los Angeles, Jonsson Comprehens Canc Ctr, 700 Tiverton, Los Angeles, CA 90024 USA

[21] Univ Calif Los Angeles, Dept Radiol Sci, 924 Westwood Blvd, Los Angeles, CA 90095 USA

[22] Univ Calif Los Angeles, C MIT, 570 Westwood Plaza, Los Angeles, CA 90095 USA

[23] Univ Tokyo, IIS, Tokyo, Japan

来源：

BIOFABRICATION | 2020年 / 12卷 / 02期

基金：

英国工程与自然科学研究理事会;

关键词：

biofabrication; bioprinting; cell printing; in vitro biological models; disease models; organoids; organ-on-a-chip; PLURIPOTENT STEM-CELLS; EXTRACELLULAR-MATRIX BIOINK; REGENERATIVE MEDICINE; GROWING TISSUES; BIOMATERIALS; TECHNOLOGIES; THERAPEUTICS; RESOLUTION; CHALLENGES; EXPANSION;

D O I：

10.1088/1758-5090/ab5158

中图分类号：

R318 [生物医学工程];

学科分类号：

0831 ;

摘要：

This bioprinting roadmap features salient advances in selected applications of the technique and highlights the status of current developments and challenges, as well as envisioned advances in science and technology, to address the challenges to the young and evolving technique. The topics covered in this roadmap encompass the broad spectrum of bioprinting; from cell expansion and novel bioink development to cell/stem cell printing, from organoid-based tissue organization to bioprinting of human-scale tissue structures, and from building cell/tissue/organ-on-a-chip to biomanufacturing of multicellular engineered living systems. The emerging application of printing-in-space and an overview of bioprinting technologies are also included in this roadmap. Due to the rapid pace of methodological advancements in bioprinting techniques and wide-ranging applications, the direction in which the field should advance is not immediately clear. This bioprinting roadmap addresses this unmet need by providing a comprehensive.summary and recommendations useful to experienced researchers and newcomers to the field.

引用

页数：33

共 87 条

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