Cranberry extract supplementation exerts preventive effects through alleviating Aβ toxicity in Caenorhabditis elegans model of Alzheimer's disease

被引：0

作者：

Guo Hong ^{[1
,2
]}

Dong Yu-Qing ^{[2
,3
]}

Ye Bo-Ping ^{[1
]}

机构：

[1] China Pharmaceut Univ, Sch Life Sci & Technol, Nanjing 210009, Jiangsu, Peoples R China

[2] Clemson Univ, Dept Biol Sci, Clemson, SC 29634 USA

[3] Clemson Univ, Inst Engaged Aging, Clemson, SC 29634 USA

来源：

CHINESE JOURNAL OF NATURAL MEDICINES | 2016年 / 14卷 / 06期

关键词：

A beta toxicity; Cranberry polyphenols; Prevention; Body paralysis; Caenorhabditis elegans; AMYLOID PEPTIDE TOXICITY; C-ELEGANS; LIFE-SPAN; HEALTH; GENETICS; CHEMOTAXIS; LONGEVITY; PRODUCTS;

D O I：

暂无

中图分类号：

R [医药、卫生];

学科分类号：

10 ;

摘要：

Cranberry extract (CBE) rich in polyphenols are potent to delay paralysis induced by alleviating beta-amyloid (A beta) toxicity in C. elegans model of Alzheimer's disease (AD). In order to better apply CBE as an anti-AD agent efficiently, we sought to deterrmine whether preventive or therapeutic effect contributes more prominently toward CBE's anti-AD activity. As the level of A beta toxicity and memory health are two major pathological parameters in AD, in the present study, we compared the effects of CBE on A beta toxicity and memory health in the C. elegans AD model treated with preventive and therapeutic protocols. Our results revealed that CBE prominently showed the preventive efficacy, providing a basis for further investigation of these effects in mammals.

引用

页码：427 / 433

页数：7

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