The role of ghrelin in the organism

被引：0
作者：
Polinska, Beata [1 ]
Matowicka-Karna, Joanna [1 ]
Kemona, Halina [1 ]
机构：
[1] Uniwersytet Med Bialymstoku, Zaklad Lab Diagnost Klin, PL-15269 Bialystok, Poland
来源：
POSTEPY HIGIENY I MEDYCYNY DOSWIADCZALNEJ | 2011年 / 65卷
关键词：
ghrelin; control of energy balance; Helicobacter pylori; insulin secretion; obesity; bone metabolism; HELICOBACTER-PYLORI INFECTION; PLASMA GHRELIN; ACYLATED GHRELIN; GASTRIC GHRELIN; FOOD-INTAKE; BODY-WEIGHT; EXPRESSION; LEPTIN; APPETITE; SECRETION;
D O I：
暂无
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Ghrelin was discovered in 1999 as an endogenous ligand of the growth hormone secretagogue receptor (GHS-R). About 60-70% of ghrelin in the blood is released from oxyntic cells (X/A-like cells) of the stomach body and fundus. Ghrelin acts via interactions with specific receptors located, for example, in the hypothalamus, pituitary gland, pancreas, kidneys, myocardium, blood vessels, adipose tissue, ovaries and placenta. Ghrelin is directly related to the control of energy balance through appetite stimulation, food intake increase and meal initiation as well as reduction of adipose tissue utilization. Moreover, ghrelin increases hydrochloric acid secretion and gastrin release, controls gastric motility, and also protects the mucous membrane of the stomach and intestine. Besides its effects on the gastrointestinal tract, ghrelin influences the cardiovascular system, bone metabolism, insulin secretion, gonad function and the immune system. It exerts anti-inflammatory effects and inhibits apoptosis of cardiomyocytes and endothelium. The plasma ghrelin level depends on the nutrition level and lifestyle factors. This article describes the most important functions of ghrelin in the organism.
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页码：1 / 7
页数：7
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共 47 条
  • [1] ADAMS CE, OBES REV IN PRESS
  • [2] Blaser MJ, 2004, J CLIN INVEST, V113, P321, DOI [10.1172/JCI200420925, 10.1172/JCI20925]
  • [3] Exercise-induced suppression of acylated ghrelin in humans
    Broom, D. R.
    Stensel, D. J.
    Bishop, N. C.
    Burns, S. F.
    Miyashita, M.
    [J]. JOURNAL OF APPLIED PHYSIOLOGY, 2007, 102 (06) : 2165 - 2171
  • [4] The endogenous growth hormone secretagogue (ghrelin) is synthesized and secreted by chondrocytes
    Caminos, JE
    Gualillo, O
    Lago, F
    Otero, M
    Blanco, M
    Gallego, R
    Garcia-Caballero, T
    Goldring, MB
    Casanueva, FF
    Gomez-Reino, JJ
    Dieguez, C
    [J]. ENDOCRINOLOGY, 2005, 146 (03) : 1285 - 1292
  • [5] Ghrelin in the regulation of body weight and metabolism
    Castaneda, T. R.
    Tong, J.
    Datta, R.
    Culler, M.
    Tschoep, M. H.
    [J]. FRONTIERS IN NEUROENDOCRINOLOGY, 2010, 31 (01) : 44 - 60
  • [6] Influence of H pylori on plasma ghrelin in patients without atrophic gastritis
    Cindoruk, Mehmet
    Yetkin, Ilhan
    Deger, Serpil Muge
    Karakan, Tarkan
    Kan, Erdal
    Unal, Selahattin
    [J]. WORLD JOURNAL OF GASTROENTEROLOGY, 2007, 13 (10) : 1595 - 1598
  • [7] Ghrelin and the short- and long-term regulation of appetite and body weight
    Cummings, David E.
    [J]. PHYSIOLOGY & BEHAVIOR, 2006, 89 (01) : 71 - 84
  • [8] A preprandial rise in plasma ghrelin levels suggests a role in meal initiation in humans
    Cummings, DE
    Purnell, JQ
    Frayo, RS
    Schmidova, K
    Wisse, BE
    Weigle, DS
    [J]. DIABETES, 2001, 50 (08) : 1714 - 1719
  • [9] Ghrelin stimulates gastric emptying but is without effect on acid secretion and gastric endocrine cells
    de la Cour, CD
    Lindström, E
    Norlén, P
    Håkanson, RH
    [J]. REGULATORY PEPTIDES, 2004, 120 (1-3) : 23 - 32
  • [10] Gastrointestinal targets of appetite regulation in humans
    Delzenne, N.
    Blundell, J.
    Brouns, F.
    Cunningham, K.
    De Graaf, K.
    Erkner, A.
    Lluch, A.
    Mars, M.
    Peters, H. P. F.
    Westerterp-Plantenga, M.
    [J]. OBESITY REVIEWS, 2010, 11 (03) : 234 - 250
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