Prefrontal Plasticity after a 3-Month Exercise Intervention in Older Adults Relates to Enhanced Cognitive Performance

被引：15

作者：

Soshi, Takahiro ^{[1
]}

Andersson, Michael ^{[2
]}

Kawagoe, Toshikazu ^{[3
]}

Nishiguchi, Shu ^{[4
]}

Yamada, Minoru ^{[5
]}

Otsuka, Yuki ^{[6
]}

Nakai, Ryusuke ^{[6
]}

Abe, Nobuhito ^{[6
]}

Aslah, Adibah ^{[7
]}

Igasaki, Tomohiko ^{[7
]}

Sekiyama, Kaoru ^{[1
]}

机构：

[1] Kyoto Univ, Grad Sch Adv Integrated Studies Human Survivabil, Sakyo Ku, 1 Yoshida Naka Adachi Cho, Kyoto 6068306, Japan

[2] Umea Ctr Funct Brain Imaging, S-90187 Umea, Sweden

[3] Rikkyo Univ, Coll Contemporary Psychol, Niiza, Saitama 3528558, Japan

[4] NTT Data Inst Management Consulting Inc, Chiyoda Ku, Tokyo 1020093, Japan

[5] Univ Tsukuba, Grad Sch Comprehens Human Sci, Bunkyo Ku, Tokyo 1120012, Japan

[6] Kyoto Univ, Kokoro Res Ctr, Sakyo Ku, Kyoto 6068501, Japan

[7] Kumamoto Univ, Dept Human & Environm Informat, Chuo Ku, Kumamoto 8608555, Japan

来源：

CEREBRAL CORTEX | 2021年 / 31卷 / 10期

关键词：

aging; brain structure; cognitive improvement; exercise intervention; prefrontal cortex; FUNCTIONAL ACTIVATION CHANGES; SURFACE-BASED ANALYSIS; HUMAN CEREBRAL-CORTEX; WORKING-MEMORY; PHYSICAL-ACTIVITY; AEROBIC EXERCISE; BRAIN ACTIVITY; RESTING-STATE; GEOMETRICALLY ACCURATE; MATTER VOLUME;

D O I：

10.1093/cercor/bhab102

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

This study examined exercise intervention effects on older adults' brain structures and function. Brain data were analyzed from 47 healthy adults between 61 and 82 years of age who, in a previous study, showed cognitive improvement following a 3-month intervention. The participants were assigned to a motor exercise intervention group (n=24), performing exercise training programs for a 12-week period, or a waiting control group (n=23), abstaining from any exercise program. Structural analysis of the frontal cortex and hippocampus revealed increased gray matter volume and/or thickness in several prefrontal areas in the intervention group and reduced hippocampal gray matter volume in the control group. Importantly, the volume increase in the middle frontal sulcus in the intervention group was associated with a general cognitive improvement after the intervention. Functional analysis showed that the prefrontal functional connectivity during a working memory task differently changed in response to the intervention or waiting in the two groups. The functional connectivity decreased in the intervention group, whereas the corresponding connectivity increased in the control group, which was associated with maintaining cognitive performance. The current longitudinal findings indicate that short-term exercise intervention can induce prefrontal plasticity associated with cognitive performance in older adults.

引用

页码：4501 / 4517

页数：17

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