The Prevailing Role of Topoisomerase 2 Beta and its Associated Genes in Neurons

被引：2

作者：

Neha, S. ^{[1
]}

Dholaniya, Pankaj Singh ^{[1
]}

机构：

[1] Univ Hyderabad, Sch Life Sci, Dept Biotechnol & Bioinformat, Hyderabad 500046, Telangana, India

来源：

MOLECULAR NEUROBIOLOGY | 2021年 / 58卷 / 12期

关键词：

Top2b; Neuron; Topoisomerases; Development; Degeneration; Senescence; FIBROBLAST GROWTH-FACTORS; CELL-ADHESION MOLECULE; II-BETA; TRANSCRIPTION FACTOR; ALZHEIMERS-DISEASE; DNA TOPOISOMERASES; ADULT NEUROGENESIS; NEURAL DEVELOPMENT; CEREBRAL-CORTEX; AXON-GUIDANCE;

D O I：

10.1007/s12035-021-02561-0

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Topoisomerase 2 beta (TOP2 beta) is an enzyme that alters the topological states of DNA by making a transient double-strand break during the transcription process. The direct interaction of TOP2 beta with DNA strand results in transcriptional regulation of certain genes and some studies have suggested that a particular set of genes are regulated by TOP2 beta, which have a prominent role in various stages of neuron from development to degeneration. In this review, we discuss the role of TOP2 beta in various phases of the neuron's life. Based on the existing reports, we have compiled the list of genes, which are directly regulated by the enzyme, from different studies and performed their functional classification. We discuss the role of these genes in neurogenesis, neuron migration, fate determination, differentiation and maturation, generation of neural circuits, and senescence.

引用

页码：6443 / 6459

页数：17

共 174 条

[1] AUTORADIOGRAPHIC INVESTIGATION OF CELL PROLIFERATION IN BRAINS OF RATS AND CATS [J].

ALTMAN, J .

ANATOMICAL RECORD, 1963, 145 (04) :573-&

[2] ARE NEW NEURONS FORMED IN BRAINS OF ADULT MAMMALS [J].

ALTMAN, J .

SCIENCE, 1962, 135 (3509) :1127-&

[3] Robo1 regulates the development of major axon tracts and interneuron migration in the forebrain [J].

Andrews, William ;

Liapi, Anastasia ;

Plachez, Celine ;

Camurri, Laura ;

Zhang, Jiangyang ;

Mori, Susumu ;

Murakami, Fujio ;

Parnavelas, John G. ;

Sundaresan, Vasi ;

Richards, Linda J. .

DEVELOPMENT, 2006, 133 (11) :2243-2252

[4] Slit-Robo interactions during cortical development [J].

Andrews, William D. ;

Barber, Melissa ;

Parnavelas, John G. .

JOURNAL OF ANATOMY, 2007, 211 (02) :188-198

[5] Receptor tyrosine kinase ErbB4 modulates neuroblast migration and placement in the adult forebrain [J].

Anton, ES ;

Ghashghaei, HT ;

Weber, JL ;

McCann, C ;

Fischer, TM ;

Cheung, ID ;

Gassmann, M ;

Messing, A ;

Klein, R ;

Schwab, MH ;

Lloyd, KCK ;

Lai, C .

NATURE NEUROSCIENCE, 2004, 7 (12) :1319-1328

[6] P53, apoptosis and axon-guidance molecules [J].

Arakawa, H .

CELL DEATH AND DIFFERENTIATION, 2005, 12 (08) :1057-1065

[7]

Austin CA, 1998, BIOESSAYS, V20, P215, DOI 10.1002/(SICI)1521-1878(199803)20:3<215::AID-BIES5>3.0.CO

[8]

2-Q

[9] SYT1-associated neurodevelopmental disorder: a case series [J].

Baker, Kate ;

Gordon, Sarah L. ;

Melland, Holly ;

Bumbak, Fabian ;

Scott, Daniel J. ;

Jiang, Tess J. ;

Owen, David ;

Turner, Bradley J. ;

Boyd, Stewart G. ;

Rossi, Mari ;

Al-Raqad, Mohammed ;

Elpeleg, Orly ;

Peck, Dawn ;

Mancini, Grazia M. S. ;

Wilke, Martina ;

Zollino, Marcella ;

Marangi, Giuseppe ;

Weigand, Heike ;

Borggraefe, Ingo ;

Haack, Tobias ;

Stark, Zornitza ;

Sadedin, Simon ;

Tan, Tiong Yang ;

Jiang, Yunyun ;

Gibbs, Richard A. ;

Ellingwood, Sara ;

Amaral, Michelle ;

Kelley, Whitley ;

Kurian, Manju A. ;

Cousin, Michael A. ;

Raymond, F. Lucy .

BRAIN, 2018, 141 :2576-2591

[10] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

← 1 2 3 4 5 6 7 8 9 10 →