Stereoselective synthesis of (-)-microcarpalide

被引：27

作者：

Chavan, SP ^{[1
]}

Praveen, C ^{[1
]}

机构：

[1] Natl Chem Lab, Div Organ Chem, Pune 411008, Maharashtra, India

来源：

TETRAHEDRON LETTERS | 2005年 / 46卷 / 11期

关键词：

microcarpalide; ring-closing metathesis; sharpless asymmetric dihydroxylation; Claisen ortho ester rearrangement; cis-2-butene-1,4-diol;

D O I：

10.1016/j.tetlet.2005.01.052

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A highly convergent and efficient synthesis of (-)-microcarpalide, a 10-membered lactone displaying remarkable microfilament disrupting activity is described. Ring-closing metathesis and Sharpless asymmetric dihydroxylations are the key steps. Our strategy highlights the application of novel hydroxy lactone precursors for the stereoselective synthesis of (-)-microcarpalide. (C) 2005 Elsevier Ltd. All rights reserved.

引用

页码：1939 / 1941

页数：3

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