Rho family GTPases and dendrite plasticity

被引：60
作者：
Negishi, M [1 ]
Katoh, H [1 ]
机构：
[1] Kyoto Univ, Grad Sch Biostudies, Mol Neurobiol Lab, Sakyo Ku, Kyoto 6068502, Japan
来源：
NEUROSCIENTIST | 2005年 / 11卷 / 03期
关键词：
Rho; Rnd; dendrite; spine; mental retardation;
D O I：
10.1177/1073858404268768
中图分类号：
R74 [神经病学与精神病学];
学科分类号：
摘要：
Dendrite structures exert a profound influence on neuronal information processing. The Rho family GTPases have been implicated in the regulation of dendritic development. Among them, Rho, Rac, and Cdc42 have been characterized extensively, and Rac and Cdc42 promote dendrite growth and branching, whereas Rho acts as a negative regulator for dendrite growth. Recently, other members of Rho family GTPases, including Rnd1 and Rnd2, have also been shown to be involved in the regulation of dendrite development. Rnd1 promotes spine maturation, and Rnd2 stimulates dendrite branching through its specific effector, Rapostlin. Thus, a variety of Rho family GTPases play important roles in dendritic development.
引用
收藏
页码：187 / 191
页数：5
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