Will any dimer do?

被引：38

作者：

Ballinger, MD ^{[1
]}

Wells, JA ^{[1
]}

机构：

[1] Sunesis Pharmaceut Inc, Redwood City, CA 94063 USA

来源：

NATURE STRUCTURAL BIOLOGY | 1998年 / 5卷 / 11期

关键词：

D O I：

10.1038/2911

中图分类号：

Q5 [生物化学]; Q7 [分子生物学];

学科分类号：

071010 ; 081704 ;

摘要：

New structural information on the interaction of erythropoietin with its receptor suggests that the orientation of receptor dimers is critical to intracellular activation.

引用

页码：938 / 940

页数：3

共 19 条

[1] SELECTABLE RETROVIRUS VECTORS ENCODING FRIEND-VIRUS GP55 OR ERYTHROPOIETIN INDUCE POLYCYTHEMIA WITH DIFFERENT PHENOTYPIC-EXPRESSION AND DISEASE PROGRESSION [J].

AHLERS, N ;

HUNT, N ;

JUST, U ;

LAKER, C ;

OSTERTAG, W ;

NOWOCK, J .

JOURNAL OF VIROLOGY, 1994, 68 (11) :7235-7243

[2] Peptide agonist of the thrombopoietin receptor as potent as the natural cytokine [J].

Cwirla, SE ;

Balasubramanian, P ;

Duffin, DJ ;

Wagstrom, CR ;

Gates, CM ;

Singer, SC ;

Davis, AM ;

Tansik, RL ;

Mattheakis, LC ;

Boytos, CM ;

Schatz, PJ ;

Baccanari, DP ;

Wrighton, NC ;

Barrett, RW ;

Dower, WJ .

SCIENCE, 1997, 276 (5319) :1696-1699

[3] Activation of the erythropoietin (EPO) receptor by bivalent anti-EPO receptor antibodies [J].

Elliott, S ;

Lorenzini, T ;

Yanagihara, D ;

Chang, D ;

Elliott, G .

JOURNAL OF BIOLOGICAL CHEMISTRY, 1996, 271 (40) :24691-24697

[4] RATIONAL DESIGN OF POTENT ANTAGONISTS TO THE HUMAN GROWTH-HORMONE RECEPTOR [J].

FUH, G ;

CUNNINGHAM, BC ;

FUKUNAGA, R ;

NAGATA, S ;

GOEDDEL, DV ;

WELLS, JA .

SCIENCE, 1992, 256 (5064) :1677-1680

[5] Amino-terminal dimerization of an erythropoietin mimetic peptide results in increased erythropoietic activity [J].

Johnson, DL ;

Farrell, FX ;

Barbone, FP ;

McMahon, FJ ;

Tullai, J ;

Kroon, D ;

Freedy, J ;

Zivin, RA ;

Mulcahy, LS ;

Jolliffe, LK .

CHEMISTRY & BIOLOGY, 1997, 4 (12) :939-950

[6] The beta chain of the interleukin-3 receptor functionally associates with the erythropoietin receptor [J].

Jubinsky, PT ;

Krijanovski, OI ;

Nathan, DG ;

Tavernier, J ;

Sieff, CA .

BLOOD, 1997, 90 (05) :1867-1873

[7] ACTIVATION OF CELL-GROWTH BY BINDING OF FRIEND SPLEEN FOCUS-FORMING VIRUS GP55 GLYCOPROTEIN TO THE ERYTHROPOIETIN RECEPTOR [J].

LI, JP ;

DANDREA, AD ;

LODISH, HF ;

BALTIMORE, D .

NATURE, 1990, 343 (6260) :762-764

[8]

LIVNAH, 1998, NATURE STRUCT BIOL, V5, P993

[9] Functional mimicry of a protein hormone by a peptide agonist: The EPO receptor complex at 2.8 angstrom [J].

Livnah, O ;

Stura, EA ;

Johnson, DL ;

Middleton, SA ;

Mulcahy, LS ;

Wrighton, NC ;

Dower, WJ ;

Jolliffe, LK ;

Wilson, IA .

SCIENCE, 1996, 273 (5274) :464-471

[10] A sequential dimerization mechanism for erythropoietin receptor activation [J].

Matthews, DJ ;

Topping, RS ;

Cass, RT ;

Giebel, LB .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 1996, 93 (18) :9471-9476

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