Evolving insight into the role of mitochondrial DNA mutations in aging

被引：4
|
作者：
Kujoth, Gregory C. [1 ]
Prolla, Tomas A. [1 ]
机构：
[1] Univ Wisconsin, Dept Genet & Med Genet, Madison, WI 53706 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 01期
关键词：
mtDNA; mutations; deletions; polg; mice; random mutation capture;
D O I：
10.1016/j.exger.2007.09.010
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Mitochondria have occupied a central place in theories on the underlying cellular mechanisms of eukaryotic aging for several decades and much debate has ensued regarding the role of oxidative stress and mitochondrial genomic damage in these processes. Mouse models with greatly enhanced mitochondrial mutagenesis have produced dramatic aging-like phenotypes but recent results have led some to reassess whether such models are relevant to naturally occurring aging mechanisms. Here, we discuss the evolving insight that may be gained from these models regarding the contribution of mitochondrial DNA mutations to aging. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：20 / 23
页数：4
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