Evolving insight into the role of mitochondrial DNA mutations in aging

被引：4
|
作者：
Kujoth, Gregory C. [1 ]
Prolla, Tomas A. [1 ]
机构：
[1] Univ Wisconsin, Dept Genet & Med Genet, Madison, WI 53706 USA
来源：
EXPERIMENTAL GERONTOLOGY | 2008年 / 43卷 / 01期
关键词：
mtDNA; mutations; deletions; polg; mice; random mutation capture;
D O I：
10.1016/j.exger.2007.09.010
中图分类号：
R592 [老年病学]; C [社会科学总论];
学科分类号：
03 ; 0303 ; 100203 ;
摘要：
Mitochondria have occupied a central place in theories on the underlying cellular mechanisms of eukaryotic aging for several decades and much debate has ensued regarding the role of oxidative stress and mitochondrial genomic damage in these processes. Mouse models with greatly enhanced mitochondrial mutagenesis have produced dramatic aging-like phenotypes but recent results have led some to reassess whether such models are relevant to naturally occurring aging mechanisms. Here, we discuss the evolving insight that may be gained from these models regarding the contribution of mitochondrial DNA mutations to aging. (C) 2007 Elsevier Inc. All rights reserved.
引用
收藏
页码：20 / 23
页数：4
相关论文
共 50 条
  • [11] Mitochondrial DNA mutations and aging: a case closed?
    Konstantin Khrapko
    Jan Vijg
    Nature Genetics, 2007, 39 : 445 - 446
  • [12] Mitochondrial DNA mutations and apoptosis in mammalian aging
    Kujoth, Gregory C.
    Leeuwenburgh, Christiaan
    Prolla, Tomas A.
    CANCER RESEARCH, 2006, 66 (15) : 7386 - 7389
  • [13] Mitochondrial DNA Mutations in Disease, Aging, and Neurodegeneration
    Reeve, Amy K.
    Krishnan, Kim J.
    Turnbull, Doug
    MITOCHONDRIA AND OXIDATIVE STRESS IN NEURODEGENERATIVE DISORDERS, 2008, 1147 : 21 - 29
  • [14] Somatic Mitochondrial DNA Mutations in Mammalian Aging
    Larsson, Nils-Goeran
    ANNUAL REVIEW OF BIOCHEMISTRY, VOL 79, 2010, 79 : 683 - 706
  • [15] Mitochondrial DNA mutations and aging: a case closed?
    Khrapko, Konstantin
    Vijg, Jan
    NATURE GENETICS, 2007, 39 (04) : 445 - 446
  • [16] Mitochondrial DNA mutations and aging: devils in the details?
    Khrapko, Konstantin
    Vijg, Jan
    TRENDS IN GENETICS, 2009, 25 (02) : 91 - 98
  • [17] Mitochondrial DNA mutations, oxidative stress, and aging
    Golden, TR
    Melov, S
    MECHANISMS OF AGEING AND DEVELOPMENT, 2001, 122 (14) : 1577 - 1589
  • [18] Role of mitochondrial DNA mutations in periodontitis
    Gopalakrishna, Praturi
    Govindaraj, Periyasamy
    Vanniarajan, Ayyasamy
    Chandra, Rampalli Viswa
    Reddy, Aileni Amarendra
    Singh, Laiji
    Thangaraj, Kumarasamy
    BIOCHIMICA ET BIOPHYSICA ACTA-BIOENERGETICS, 2008, 1777 : S77 - S78
  • [19] Role of mitochondrial DNA in human aging
    Attardi, G
    MITOCHONDRION, 2002, 2 (1-2) : 27 - 37
  • [20] Role of mitochondrial DNA mutations in human aging: Implications for the central nervous system and muscle
    Brierley, EJ
    Johnson, MA
    Lightowlers, RN
    James, OFW
    Turnbull, DM
    ANNALS OF NEUROLOGY, 1998, 43 (02) : 217 - 223
12345