Directly observed antiretroviral therapy to reduce genital tract and plasma HIV-1 RNA in women with poor adherence

被引：6
作者：
Harwell, JI [1 ]
Flanigan, TP
Mitty, JA
Macalino, GE
Caliendo, AM
Ingersoll, J
Stenzel, MS
Carpenter, CCJ
Cu-Uvin, S
机构：
[1] Brown Univ, Providence, RI 02912 USA
[2] Emory Univ, Atlanta, GA 30322 USA
[3] Vancouver Clin, Vancouver, WA USA
来源：
AIDS | 2003年 / 17卷 / 13期
关键词：
D O I：
10.1097/00002030-200309050-00021
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
Six women with substance abuse and poor adherence histories received daily antiretroviral directly observed therapy (DOT). Cervicovaginal lavage (CVL) and plasma HIV-1-RNA levels were measured at baseline, 1 month, 3 months, and 6 months. All subjects had undetectable (below 2.6 log(10) copies/ml) CVL HIV-1-RNA levels by 3 months and undetectable plasma HIV-1-RNA levels by 6 months. The mean CD4 cell increase was 76 cells/mm(3). DOT appears effective and may reduce infectiousness in this high-risk population.
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收藏
页码：1990 / 1993
页数：4
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